heliodermin

MW 5,900 peptide with secretin-like properties

Also Known As:

exendin 2; exendin-2; helodermin; Helospectin I, 5-L-isoleucine-8-L-glutamine-9-L-glutamine-24-L-alanine-30-L-arginine-34-de-L-arginine-36-L-prolinamide-37-de-L-serine-38-de-L-serine-

Networked: 19 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intercellular Signaling Peptides and Proteins: 29768
    - heliodermin: 19
- Peptides: 82426
  - Intercellular Signaling Peptides and Proteins: 29768
    - heliodermin: 19
Biological Factors: 2472
- Intercellular Signaling Peptides and Proteins: 29768
  - heliodermin: 19

Related Diseases

1.	Thyroid Neoplasms (Thyroid Cancer) 08/01/1989 - "Notably high concentrations were demonstrated in the thyroid gland, and immunocytochemical studies revealed intense helodermin-like immunostaining in thyroid C cells and medullary thyroid carcinoma cells. " 01/01/1988 - "Is helodermin produced by medullary thyroid carcinoma cells and normal C-cells? " 01/01/1988 - "In the present study 8 human medullary thyroid carcinomas as well as 4 normal thyroid glands were examined immunocytochemically for the presence of helodermin using an antiserum raised against helodermin-(5-35) that does not cross-react with VIP or secretin. " 01/01/1988 - "The results suggest that a peptide chemically related to helodermin is a constituent of human medullary thyroid carcinoma cells as well as of normal C-cells." 10/29/1990 - "Helodermin-like and salmon calcitonin (sCT)-like immunoreactivities co-existed in a subset of human calcitonin (hCT)-containing cells in normal human thyroid tissue and medullary thyroid carcinomas. "
2.	Lymphoma (Lymphomas) 01/01/1991 - "Molecular characterization of helodermin-preferring VIP receptors in SUP T1 lymphoma cells: evidence for receptor glycosylation." 09/01/1989 - "Pharmacological characterization of the novel helodermin/VIP receptor present in human SUP-T1 lymphoma cell membranes." 08/01/1989 - "Homologous and heterologous regulation of the helodermin/vasoactive-intestinal-peptide response in the murine radiation leukemia-virus-induced lymphoma cell line BL/VL3." 09/01/1989 - "VIP/helodermin receptors and PGE1 receptors coupled to adenylate cyclase underwent rapid homologous desensitization and/or down regulation in the human lymphoma SUP-T1 cell line: helodermin- and PGE1-stimulated adenylate cyclase activities in membranes decreased by 75% and 80%, respectively, after a 16-hr incubation of cells with 30 nM VIP or 0.1 microM PGE1. " 01/01/1990 - "We characterized a new type of vasoactive intestinal peptide (VIP) receptors in the CD4+ Stanford University Pediatric (SUP)-T1 lymphoma cell line, by comparing receptor occupancy [in the presence of (125I)helodermin and (125I)(acetyl-His1)VIP] and adenylate cyclase activation (in the presence of GTP). "
3.	Small Cell Lung Carcinoma (Small Cell Lung Cancer) 11/01/1990 - "Characterization of VIP- and helodermin-preferring receptors on human small cell lung carcinoma cell lines." 01/01/1993 - "Small-cell lung carcinoma: inhibition of proliferation by vasoactive intestinal peptide and helodermin and enhancement of inhibition by anti-bombesin antibody."
4.	Hypotension (Low Blood Pressure) 12/01/1998 - "Helodermin produced hypotension in a dose-dependent manner with approximately similar potency and duration to VIP. " 12/01/1998 - "Glibenclamide-sensitive hypotension produced by helodermin assessed in the rat." 01/01/1986 - "Intravenous injection of synthetic helodermin produced prolonged systemic hypotension and tachycardia; and, similar to VIP, it increased the common carotid arterial blood flow while those of the superior mesenteric and femoral arteries were decreased. " 12/01/1998 - "These findings suggest that helodermin-produced hypotension is partly attributable to the activation of glibenclamide-sensitive K+ channels (K(ATP) channels), which presumably exist on arterial smooth muscle cells. " 12/01/1998 - "Oxyhemoglobin did not affect helodermin-induced hypotension, whereas it shortened the duration of acetylcholine (ACh)-produced hypotension. "
5.	Lung Injury 10/01/1993 - "Paraquat-induced lung injury: prevention by vasoactive intestinal peptide and related peptide helodermin."

Related Drugs and Biologics

1.	Secretin
2.	Vasoactive Intestinal Peptide (VIP (Vasoactive Intestinal Peptide))
3.	Vasoactive Intestinal Peptide Receptors (Vasoactive Intestinal Peptide Receptor)
4.	Peptides (Polypeptides)
5.	Adenylyl Cyclases (Adenylyl Cyclase)
6.	Alprostadil (Muse)
7.	Lectins
8.	Prostaglandin Receptors (Prostaglandin Receptor)
9.	Paraquat
10.	Oxyhemoglobins (Oxyhemoglobin)

Related Therapies and Procedures

1.	Intravenous Injections
2.	Controlled Hypotension