destruxin E

cyclodepsipeptide from entomopathogenic fungus Metarhyzium anisopliae; structure given in first source

Also Known As:

E-destruxin; cyclo(N-methyl-L-alanyl-beta-alanyl-4,5-anhydro-3-deoxy-D-erythro-pentonoyl-L-prolyl-L-isoleucyl-N-methyl-L-valyl); destruxin DE

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

1.	Tuberculosis (Tuberculoses) 09/01/2006 - "Chemical investigation of the cytotoxic and anti-tuberculosis active butanone extract obtained from the growth media of the marine-derived fungus Beauveria felina led to the isolation of two new destruxins, [beta-Me-Pro] destruxin E chlorohydrin (1) and pseudodestruxin C (3), along with five known cyclic depsipeptides. "
2.	Paralysis (Palsy) 08/01/1997 - "The insecticidal properties on the Galleria mellonella larvae (paralysis and lethal effect) of these analogs are presented in comparison with the natural destruxin E. "
3.	Leukemia 01/01/1987 - "The activity of destruxin E, a cryptogamic toxin isolated from the hyphomycete Metarhizium anisopliae, was studied on mouse leukemia cells (L 1210 and P 388) in culture. "
4.	Hepatocellular Carcinoma (Hepatoma) 12/01/2013 - "Destruxin A, destruxin B and destruxin E isolated from entomopathogenic fungus Metarhizium anisopliae showed a strong suppressive effect on the replication of hepatitis B virus (HBV) in human hepatoma cells. "
5.	Carcinoma (Carcinomatosis) 09/10/2002 - "In the course of screening for compounds that induce apoptosis in EGFR-overexpressing human epidermal carcinoma A431 cells from secondary metabolites of microorganisms, we found that vacuolar-type H(+)-ATPase (V-ATPase) inhibitors, such as concanamycin B and destruxin E, induced apoptosis only when the cells were stimulated with EGF. "

1.	Depsipeptides
2.	Proton-Translocating ATPases (ATPase, H+)
3.	Epidermal Growth Factor (EGF)
4.	Adenosine Triphosphatases (ATPase)
5.	pseudodestruxin C
6.	destruxin B
7.	destruxin A
8.	concanamycin B