dioxadet

03/01/2016 - "Both heat and new chemotherapeutic drug dioxadet in hyperthermic intraperitoneal chemoperfusion improved survival in rat ovarian cancer model."
01/01/2014 - "The study of antitumor efficacy of dioxadet in chemoperfusion treatment of ascitic ovarian cancer was carried out in 125 Wistar female rats. "
01/01/2014 - "Intraperitoneal administration of dioxadet as well as chemoperfusion was performed once in 48 hours after the ovarian cancer inoculation. "
01/01/2014 - "[Antitumor effect of dioxadet in intraperitoneal chemoperfusion treatment for advanced ovarian cancer in experimental setting]."
06/01/2016 - "Experimental study of antitumour activity and effects on leukocyte count of intraperitoneal administration and hyperthermic intraperitoneal chemoperfusion (HIPEC) with dioxadet in a rat model of ovarian cancer."

11/01/2018 - "Morphological changes in the ovarian carcinoma cells of Wistar rats induced by chemotherapy with cisplatin and dioxadet."
01/01/2014 - "An experimental technology of normothermic intraperitoneal chemoperfusion and hyperthermic intraperitoneal chemoperfusion with cisplatin and dioxadet has been elaborated to treat abdominal carcinomatosis in ovarian cancer. "
03/01/1987 - "After performing selective continuous monochemotherapy (with dioxadet, cis-platinum or adriamycin) of inoperable local carcinoma of the urinary bladder, the full or partial effect was achieved in 6 of 12 patients, and progress of the disease was noted in one patient only."
11/01/2018 - "Experimentally, a comparative analysis of the antitumor efficacy of the two cytostatics, cisplatin and dioxadet, that are commonly used for chemotherapy of disseminated ovarian carcinoma has been performed. "

01/01/1998 - "[The use of dioxadet in chemoembolization of the hepatic artery in primary and metastatic cancer of the liver]."
11/01/1994 - "The authors confirm the efficacy of treating primary and metastatic cancer of the liver by selective blocking of vessels in the involved liver part with an oily x-ray contrast agent with a citostatic dioxadet. "

11/18/2022 - "The IC50 values determined for dioxadet nanoformulations were in the range of 0.47−4.98 μg/mL for cancer cells, which is close to the free drug’s efficacy (2.60−4.14 μg/mL). "
01/01/2011 - "However, the tumor cells growth was also significantly inhibited in mice receiving half of dioxadet dose. "
01/01/1986 - "[Effect of dioxadet on tumors transplanted to the brain]."
01/01/1996 - "One of the drugs, dioxadet passed the I and II stages of clinical trials and is recommended for application in chemotherapy of malignant tumors."
01/01/2011 - "Antitumor activity of dioxadet in comparison with cisplatin was studied on the model of ascitic ovarian tumor in 32 female Wistar rats. "

01/01/2011 - "In comparison with the control group dioxadet increased the average time of ascites occurrence and median of life span by 30% and 113% (p < 0.05), cisplatin increased these parameters by 28% and 147% (p < 0.05). "
01/01/1983 - "[Potentiation of the antitumor activity of dioxadet by antiestrogen para-aminobenzhydrazide in a model of ovarian ascites tumor]."