tiacrilast

structure given in first source

Also Known As:

3-(6-(methylthio)-4-oxo-4H-quinazolin-3-yl)-2-propenoic acid; Ro 223747; Ro-22-3747; 2-Propenoic acid, 3-(6-(methylthio)-4-oxo-3(4H)-quinazolinyl)-, (E)-

Networked: 4 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinazolines: 402
      - tiacrilast: 4

Related Diseases

1.	Atopic Dermatitis (Atopic Eczema) 01/01/1993 - "Topical tiacrilast, a potent mast cell degranulation inhibitor, does not improve adult atopic eczema." 01/01/1993 - "Since mast cells and their mediators are possibly involved in atopic eczema, we have studied a topically applied 3% hydrogel formulation of tiacrilast against vehicle in a multicenter, double-blind, placebo-controlled trial. "
2.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/1995 - "A total of 31 patients with plaque-type psoriasis were evaluated after treatment with a 3% Tiacrilast hydrogel and hydrogel alone, in a double-blind, placebo-controlled, within-patient comparative study. "
3.	Immediate Hypersensitivity 06/01/1986 - "Tiacrilast (Ro 22-3747) is an allergic mediator release inhibitor which has demonstrated potent oral activity in two IgE-mediated animal models of immediate hypersensitivity: the rat passive cutaneous anaphylaxis test (ID50 of 0.65 mg/kg) and a model in which anaphylactic bronchospasm is induced in passively sensitized rats (ID50 of 0.022 mg/kg). "
4.	Contact Dermatitis (Eczema, Contact) 01/01/1990 - "Effect of tiacrilast, a mast cell mediator-release inhibitor, on murine experimental contact dermatitis." 01/01/1990 - "The effect of tiacrilast, a mast cell mediator-release inhibitor, was studied in dinitrofluorobenzene-induced allergic and croton oil- or dimethyl sulfoxide-induced irritant murine contact dermatitis. "
5.	Bronchial Spasm 06/01/1986 - "Tiacrilast (Ro 22-3747) is an allergic mediator release inhibitor which has demonstrated potent oral activity in two IgE-mediated animal models of immediate hypersensitivity: the rat passive cutaneous anaphylaxis test (ID50 of 0.65 mg/kg) and a model in which anaphylactic bronchospasm is induced in passively sensitized rats (ID50 of 0.022 mg/kg). "

Related Drugs and Biologics

1.	Hydrogels
2.	Irritants (Vesicants)
3.	Immunoglobulin E (IgE)
4.	Dinitrofluorobenzene
5.	Dimethyl Sulfoxide (DMSO)
6.	Croton Oil

Related Therapies and Procedures

1.	Aftercare (After-Treatment)