2,3,6-trichloroindophenol

01/01/2019 - "TCIP-H SCCHN tumors were associated with the MAPK/ERK, JAK/STAT and mTOR/AKT signaling pathways, and were enriched in CASP8, EP300, EPHA2, HRAS mutations, CD274, PDCD1LG2, JAK2 amplifications. "
01/01/2019 - "TCIP-H SCCHN tumors were enriched in multiple immune checkpoints irrespective of HPV-status. "
01/01/2019 - "Gene set enrichment and iPANDA analyses were conducted to dissect differences in signaling pathways, somatic mutations and copy number aberrations for TCIP-H versus TCIP-L tumors, stratified by HPV status. "
01/01/2019 - "Our findings support that combinatorial immune checkpoint blockade and depletion strategies targeting Tregs in HPV-positive and M2 macrophages in HPV-negative tumors may lead to improved antitumor immune responses in patients with TCIP-H SCCHN. "
01/01/2019 - "TCIP-L SCCHN tumors were enriched for the β-catenin/WNT and Hedgehog signaling pathways, had frequent mutations in NSD1, amplifications in EGFR and YAP1, as well as CDKN2A deletions. "

11/17/2023 - "The positive predictive values of CD4+ and CD8+ T-cell positivity >0.2 % for CMV protection were: 96.3 % for CMV DNAemia prompting treatment initiation, 92.6 % for any DNAemia, 100 % for DNAemia >1000 IU/mL. The TCIP could be a useful adjunct tool in individualized management of CMV infection."
10/28/2023 - "Rate of post-TCIP CMV infection was 10.2%. "
06/01/2016 - "Recently, we showed that phosphorothioate antisense oligos against Trypanosoma cruzi inositol 1,4,5-trisphosphate receptor (TcIP(3)R) mRNA inhibit the parasite host cell infection. "

12/01/2014 - "The best predictors for high binge drinking score were premature responding in the Sx-5CSRTT, trait impulsivity in the BIS-11, and decision making in the TCIP. "

12/01/2016 - "Since Ca2+ signaling is vital for these parasites, TcIP 3R is a promising drug target for Chagas disease."
12/01/2016 - "Recently, we identified a Ca2+ channel (TcIP 3R) associated with intracellular Ca2+ stores in Trypanosoma cruzi, the parasitic protist that causes Chagas disease. "

06/06/2017 - "Methods: Spontaneous pain, paw withdrawal threshold and latency were assessed using TCIP mouse model. "
06/06/2017 - "Background: Tumor compression-induced pain (TCIP) is a complex pathological cancer pain. "