|1.||Sang, Shengmin: 10 articles (05/2014 - 05/2008)|
|2.||Ho, Chi-Tang: 7 articles (03/2015 - 05/2008)|
|3.||Chen, Huadong: 6 articles (05/2014 - 04/2012)|
|4.||Yen, Gow-Chin: 5 articles (03/2015 - 11/2010)|
|5.||Qi, Lian-Wen: 5 articles (01/2015 - 01/2012)|
|6.||Soroka, Dominique N: 5 articles (05/2014 - 01/2013)|
|7.||Kim, Sun Yeou: 4 articles (01/2015 - 08/2012)|
|8.||Liu, Qun: 4 articles (01/2015 - 01/2012)|
|9.||Warin, Renaud F: 4 articles (05/2014 - 04/2012)|
|10.||Li, Ping: 4 articles (03/2014 - 01/2012)|
11/01/2015 - "This study gives rise to the possibility of applying shogaol as an antitumor agent that can be used for the purpose of combination treatment with TRAIL in TRAIL-resistant colon tumor therapy. "
09/05/2015 - "HCC cell lines, HepG2 and Huh-7, were used to study the in vitro anti-cancer activity of 6-shogaol via the application of various molecular biology techniques. "
11/01/2013 - "In this study, the anti-cancer potential of a synthetic novel shogaol analog 3-phenyl-3-shogaol (3-Ph-3-SG) was assessed by evaluating its effects on signaling pathways. "
01/01/2013 - "The aim of the current study is to synthesize the major metabolites of -shogaol and evaluate their inhibition of growth and induction of apoptosis in human cancer cells. "
01/01/2013 - "Our previous study found that -shogaol, a major bioactive component in ginger, is extensively metabolized in cancer cells and in mice. "
|2.||Breast Neoplasms (Breast Cancer)
01/01/2015 - "The efficacy of 6-shogaol in monolayer and cancer stem cell-like spheroids raise hope for its therapeutic benefit in breast cancer treatment. "
01/01/2015 - "6-shogaol was effective in killing both breast cancer monolayer cells and spheroids at doses that were not toxic to noncancerous cells. "
01/01/2015 - "In this study, we have investigated inhibitory activity of the ginger-derived compound 6-shogaol against breast cancer cells both in monolayer and in cancer-stem cell-like spheroid culture. "
01/01/2015 - "6-Shogaol Inhibits Breast Cancer Cells and Stem Cell-Like Spheroids by Modulation of Notch Signaling Pathway and Induction of Autophagic Cell Death."
05/01/2013 - "In conclusion, the present study demonstrates for the first time that 6-shogaol and pterostilbene can inhibit invadopodium formation and MMP activity in highly invasive breast cancer cells. "
|3.||Hepatocellular Carcinoma (Hepatoma)
01/01/2014 - "Taken together, these results for the first time showed antioxidative and antiapoptotic activities of 6-shogaol in tBHP-treated hepatoma HepG2 cells, suggesting that 6-shogaol could be beneficial in hepatic disorders caused by oxidative stress."
09/05/2015 - "6-Shogaol induces cell cycle arrest and apoptosis in human hepatoma cells through pleiotropic mechanisms."
01/01/2012 - "In this work, we demonstrated that 6-shogaol induces apoptosis in human hepatocellular carcinoma cells in relation to caspase activation and endoplasmic reticulum (ER) stress signaling. "
02/07/2007 - "6-shogaol (alkanone from ginger) induces apoptotic cell death of human hepatoma p53 mutant Mahlavu subline via an oxidative stress-mediated caspase-dependent mechanism."
01/01/2012 - "6-Shogaol induces apoptosis in human hepatocellular carcinoma cells and exhibits anti-tumor activity in vivo through endoplasmic reticulum stress."
01/01/2013 - "However, little is known about the efficacy of 6-shogaol on leukemia cells. "
01/01/2013 - "The present study indicated that 6-shogaol selectively induced apoptosis in transformed and primary leukemia cells but not in normal cells. "
03/24/2010 - "This study examined the growth inhibitory effects of -shogaol, one of the pungent phenolic compounds in ginger, on human leukemia HL-60 cells. "
01/01/2013 - "Three leukemia cell lines and primary leukemia cells were used to investigate the apoptosis effect of 6-shogaol. "
01/01/2013 - "Here we investigated the underlying mechanism of 6-shogaol induced apoptosis in human leukemia cells in vitro and in vivo. "
|5.||Colonic Neoplasms (Colon Cancer)
08/09/2013 - "Together, our findings suggest that the antitumor effects of 6-shogaol are mediated through activation of PPARγ and imply that activation of PPARγ might be beneficial for breast and colon cancer treatment."
11/01/2015 - "In this study, we showed the ability of representative shogaol, which as a major component of ginger, to overcome TRAIL resistance by increasing apoptosis in colon cancer cells. "
11/01/2015 - "Therefore, we showed the functions of shogaol as a sensitizing agent to induce cell death of TRAIL-resistant colon cancer cells. "
11/01/2015 - "Shogaol overcomes TRAIL resistance in colon cancer cells via inhibiting of survivin."
01/01/2015 - "Anti-Colon Cancer Effects of 6-Shogaol Through G2/M Cell Cycle Arrest by p53/p21-cdc2/cdc25A Crosstalk."
|5.||Reactive Oxygen Species (Oxygen Radicals)
|7.||Uric Acid (Urate)
|9.||5- hydroxy- 3,6,7,8,3',4'- hexamethoxyflavone
|10.||oxidized low density lipoprotein
|1.||Heterologous Transplantation (Xenotransplantation)