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1-hydroxymethylmidazolam

metabolite of midazolam

Also Known As:

1'-hydroxymidazolam; 1-OH-MDZ; 1-hydroxymidazolam; alpha-hydroxymidazolam

Networked: 8 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzazepines: 5
      - Benzodiazepines: 8452
        Midazolam: 3777
        1-hydroxymethylmidazolam: 8

Experts

1.	Ahsman, Maurice J: 1 article (06/2010)
2.	Hanekamp, Manon: 1 article (06/2010)
3.	Mathot, Ron A A: 1 article (06/2010)
4.	Tibboel, Dick: 1 article (06/2010)
5.	Wildschut, Enno D: 1 article (06/2010)
6.	Frye, Reginald F: 1 article (10/2009)
7.	Himmelfarb, Jonathan: 1 article (10/2009)
8.	Le, Phuong: 1 article (10/2009)
9.	Leblond, Francois A: 1 article (10/2009)
10.	Naud, Judith: 1 article (10/2009)

Related Diseases

1.	Critical Illness (Critically Ill) 06/01/2010 - "After allometric scaling, clearance of midazolam and 1-hydroxymidazolam increases as a result of maturation or recovery from critical illness. " 07/15/1995 - "Conjugates of its main metabolite, alpha-hydroxymidazolam, have been shown to accumulate in renal failure but have not previously been related to the prolonged sedative effects commonly observed in critically ill patients. " 04/01/2006 - "A combined high-performance liquid chromatography-based method was developed for the benzodiazepines midazolam, 1-hydroxymidazolam, 1-hydroxymidazolam glucuronide, diazepam, and nordiazepam and for the barbiturates thiopentone and pentobarbitone in serum or plasma of critically ill patients. "
2.	Acute Kidney Injury (Acute Renal Failure) 01/01/1991 - "This study investigated the pharmacokinetics of midazolam and its main metabolite, 1-hydroxymethylmidazolam glucoronide, during long-term i.v. infusion in 39 mechanically ventilated ICU patients of whom 6 were in acute renal failure (ARF). "
3.	Renal Insufficiency (Renal Failure) 07/15/1995 - "Conjugates of its main metabolite, alpha-hydroxymidazolam, have been shown to accumulate in renal failure but have not previously been related to the prolonged sedative effects commonly observed in critically ill patients. "
4.	Neoplasms (Cancer) 01/01/2023 - "Period 1: patients with locally advanced or metastatic solid tumors received 'cocktail': caffeine 200 mg, omeprazole 20 mg, and midazolam 2 mg (single dose); period 2: after 7- to 14-day washout, patients received adavosertib 225 mg twice daily on days 1-3 (five doses), with cocktail on day 3. After cocktail alone or in combination with adavosertib administration, 24-h pharmacokinetic sampling occurred for probe substrates and their respective metabolites paraxanthine, 5-hydroxyomeprazole (5-HO), and 1'-hydroxymidazolam (1'-HM). "
5.	Chronic Kidney Failure (Chronic Renal Failure) 10/01/2009 - "We did not observe significant differences in midazolam or 1'-hydroxymidazolam clearance or area under the curve after oral administration, suggesting that CYP3A function is not changed by ESRD. "

Related Drugs and Biologics

1.	Midazolam (Versed)
2.	Cytochrome P-450 CYP3A
3.	Glucuronides
4.	Thiopental (Pentothal)
5.	Pentobarbital (Nembutal)
6.	Omeprazole (Prilosec)
7.	Hypnotics and Sedatives (Sedatives)
8.	Diazepam (Valium)
9.	Nordazepam
10.	Caffeine (No Doz)

Related Therapies and Procedures

1.	Oral Administration