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collagen type XVII (collagen XVII)

Subscribe to New Research on collagen type XVII

220 kDa glycoprotein; basement membrane component; involved in healing corneal epithelial wounds; RefSeq NM_130778 (COL17A1, human), NM_183380 (DST, human), NM_007732 (mouse)

Also Known As:

collagen XVII; 180 kDa bullous pemphigoid autoantigen; BP180 antigen; BP180 autoantigen; BP180 protein, human; BP180 protein, mouse; BPAG2 protein, human; Bpag protein, mouse; Bpag2 protein, mouse; Bullous pemphigoid antigen 2, mouse; COL17A1 protein, human; Col17a1 protein, mouse; LAD-1 protein, human; bullous pemphigoid antigen 2, human; bullous pemphigoid autoantigen, BP180; collagen alpha-1(XVII) chain; collagen, type XVII, alpha 1 chain; collagen, type XVII, alpha 1 protein, human; collagen, type XVII, alpha 1 protein, mouse; collagen, type XVII, alpha 1, human; procollagen, type XVII, alpha 1 protein, mouse; type XVII collagen

Networked: 110 relevant articles (0 outcomes, 4 trials/studies) for this Bio-Agent, Comments

Bio-Agent Context: Research Results

Experts

1.	Bruckner-Tuderman, Leena: 12 articles (08/2009 - 01/2002)
2.	Sitaru, Cassian: 9 articles (11/2008 - 01/2002)
3.	Zillikens, Detlef: 9 articles (09/2007 - 01/2002)
4.	Tasanen, Kaisa: 7 articles (04/2008 - 03/2003)
5.	Shimizu, Hiroshi: 6 articles (02/2010 - 03/2007)
6.	Nishie, Wataru: 6 articles (02/2010 - 03/2007)
7.	Hofmann, Silke C: 5 articles (07/2009 - 07/2007)
8.	Bruckner-Tuderman, L: 5 articles (05/2006 - 02/2000)
9.	Shibaki, Akihiko: 4 articles (02/2010 - 03/2007)
10.	Akiyama, Masashi: 4 articles (02/2010 - 03/2007)

Related Diseases

1.	Bullous Pemphigoid (Pemphigoid) 09/01/2007 - "The protein bullous pemphigoid antigen-2 (BPAG2/BP180/collagen type XVII) plays a key role in attachment of basal keratinocytes to epidermal basement membrane. " 07/01/2003 - "A Japanese woman had bullous eruptions on her palms and soles for two months, histopathologic examination, immunofluorescence microscopy, and ELISA for BP180 antigen led to the definitive diagnosis of dyshidrosiform pemphigoid (DP). " 03/01/2007 - "Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of indirect evidence indicating that the underlying autoantigen is collagen XVII (COL17). " 06/01/2006 - "Type XVII collagen is an autoantigen in patients with pemphigoid diseases and its gene is mutated in patients with junctional epidermolysis bullosa. " 03/01/2004 - "BACKGROUND: Bullous pemphigoid (BP) is an autoimmune blistering disease of the skin characterized by autoantibody attack on collagen XVII. OBJECTIVES: To characterize the genetic complexity of COL17A1, the gene which encodes for the autoantigen collagen XVII. The data will be used to determine whether there is an association between polymorphisms and haplotypes of COL17A1 and genetic susceptibility to development of BP. METHODS: The genetic complexity in COL17A1 was deduced by screening and then sequencing the gene. " Order ALL the reference details at left...
2.	Junctional Epidermolysis Bullosa (Epidermolysis Bullosa Letalis) 01/01/2001 - "In this study we describe six Italian patients presenting an unusually mild variant of non-Herlitz junctional epidermolysis bullosa associated with a reduced expression of type XVII collagen. " 01/01/2010 - "Collagen XVII has been identified as having a role in inherited junctional epidermolysis bullosa non-Herlitz (JEB-other, MIM #226650). " 09/01/2009 - "Collagen XVII (COL17) participates in keratinocyte adhesion and possibly migration, as COL17 defects disrupt keratinocyte-basal lamina adhesion and underlie the disease non-Herlitz junctional epidermolysis bullosa. " 05/01/2007 - "BACKGROUND: Mutations in the gene COL17A1 coding for type XVII collagen cause non-Herlitz junctional epidermolysis bullosa (nH-JEB). " 12/01/2005 - "Mutations in the collagen XVII gene, COL17A1, are associated with junctional epidermolysis bullosa. " Order ALL the reference details at left...
3.	Skin Diseases 02/01/2000 - "Despite a number of studies on autoantibody targets in blistering skin diseases, it has remained unclear whether the physiologically shed ectodomain of collagen XVII plays a role as an autoantigen. " 02/01/2000 - "Sera of 81 patients with a clinically active blistering skin disease were reacted with full-length collagen XVII, the authentic soluble ectodomain, and recombinant fragments. " 03/01/2007 - "Bullous pemphigoid (BP) is the most common serious autoimmune blistering skin disease, with a considerable body of indirect evidence indicating that the underlying autoantigen is collagen XVII (COL17). " 02/01/2000 - "The shed ectodomain of collagen XVII/BP180 is targeted by autoantibodies in different blistering skin diseases." 09/15/2009 - "Bullous pemphigoid is the most common life-threatening autoimmune blistering skin disease that affects the elderly, in which circulating IgG autoAbs are directed against epidermal type XVII collagen (COL17). " Order ALL the reference details at left...
4.	Epidermolysis Bullosa 02/01/2002 - "Generalized atrophic benign epidermolysis bullosa [GABEB (OMIM no. 226650)] is an inherited subepidermal blistering disease typically caused by null mutations in COL17A1, the gene encoding type XVII collagen. " 06/01/2001 - "However, in our patient with the generalized atrophic benign epidermolysis bullosa subtype, a small amount of type XVII collagen was detectable in the skin, and immunoblotting of cultured keratinocytes revealed that the 180-kDa protein was 10 kDa shorter. " 02/01/1998 - "Patients with generalized atrophic benign epidermolysis bullosa often show decreased expression of type XVII collagen, a transmembrane hemidesmosomal protein encoded by COL17A1. " 08/01/1997 - "Implications of intragenic marker homozygosity and haplotype sharing in a rare autosomal recessive disorder: the example of the collagen type XVII (COL17A1) locus in generalised atrophic benign epidermolysis bullosa." 02/01/1997 - "Cloning of the human type XVII collagen gene (COL17A1), and detection of novel mutations in generalized atrophic benign epidermolysis bullosa." Order ALL the reference details at left...
5.	Pemphigoid Gestationis (Herpes Gestationis) 04/01/2008 - "Pemphigoid gestationis autoantigen, transmembrane collagen XVII, promotes the migration of cytotrophoblastic cells of placenta and is a structural component of fetal membranes." 04/01/2006 - "Pemphigoid gestationis (PG) is a subepidermal autoimmune blistering disease characterized by self-reactive T and B cells specific for the transmembrane hemidesmosomal protein type XVII collagen/BP180. " 01/01/1994 - "An immunodominant and potentially pathogenic epitope associated with bullous pemphigoid (BP) and herpes gestationis (HG) has recently been mapped by our laboratory to a noncollagenous stretch of the extracellular domain of the human BP180 antigen. " 04/01/2008 - "In pemphigoid gestationis (PG), autoantibodies target collagen XVII, a hemidesmosomal transmembrane protein, which is an important element in cutaneous epithelial adhesion and signalling. " 01/01/1996 - "In conclusion, there are now three bullous diseases, bullous pemphigoid, herpes gestationis, and cicatricial pemphigoid, that are known to be associated with an autoimmune response against the extracellular domain of the BP180 antigen." Order ALL the reference details at left...

Related Drugs and Biologics

1.	Antigens
2.	Messenger RNA (mRNA)
3.	Autoantibodies
4.	Immunoglobulin G (IgG)
5.	Immunoglobulin A (IgA)
6.	kalinin
7.	Proteins (Proteins, Gene)
8.	Collagen
9.	Integrin alpha6beta4
10.	Collagen Type VII

Related Therapies and Procedures

1.	Heterologous Transplantation (Xenotransplantation)

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