7,8- dihydroxy- 9,10- epoxide- 7,8,9,10- tetrahydrobenzo(a)pyrene- 10- deoxyguanosine

deoxyguanosine attached to benzopyrene derivative through its 2-amino group

Also Known As:

BPDE-N(2)-dG; BPDE-dG; trans-(7R)-N(2)-(7beta,8alpha,9alpha-trihydroxy-7,8,9,10-tetrahydrobenzo(a)pyren-10-yl)deoxyguanosine; Guanosine, 2'-deoxy-N-(7,8,9,10-tetrahydro-7,8,9-trihydroxybenzo(a)pyren-10-yl)-, (7alpha,8beta,9beta,10alpha)-

Networked: 4 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Alexandrov, Kroum: 3 articles (09/2010 - 04/2004)
2.	Rojas, Margarita: 3 articles (09/2010 - 04/2004)
3.	Guo, Ling: 1 article (01/2019)
4.	Jiang, Xiao: 1 article (01/2019)
5.	Li, Bo-Ya: 1 article (01/2019)
6.	Sun, Xin: 1 article (01/2019)
7.	Tian, Hao-Yuan: 1 article (01/2019)
8.	Yao, Shang-Jin: 1 article (01/2019)
9.	Zhang, Rong-Jie: 1 article (01/2019)
10.	Zhang, Shu-Sheng: 1 article (01/2019)

Related Diseases

1.	Carcinogenesis 12/15/2006 - "This adduct is now considered to be critical event in tumorigenesis by BP. In this study, we investigate the contribution of cigarette smoke on the BPDE-dG formation. "
2.	Congenital Abnormalities (Deformity) 01/01/2019 - "In this study, we employed our developed LC-MS/MS method to detect and quantity BPDE-dG adducts present in 42 normal human umbilical cord blood samples and 42 birth defect cases. " 01/01/2019 - "The results indicated that under experimental conditions, BPDE-dG adducts were detected in all the human umbilical cord blood samples from the normal and birth defect groups." 01/01/2019 - "We determined that there is no significant difference in the level of BPDE-dG formation between the normal and birth defect groups. "
3.	Lung Neoplasms (Lung Cancer) 09/15/2010 - "If the formation of BPDE-dG adduct were to be inhibited or blocked in bronchial epithelial cells, so could lung cancer development. " 09/15/2010 - "We thus argue that BPDE-dG adduct could be used as a model biomarker in searching and validating of approaches to reducing lung cancer risk. " 09/15/2010 - "BPDE reacts with DNA also at N(6) position of adenine, producing the minor N(6)-deoxyadenosine adduct, but BPDE-dG adduct is a well-established risk factor for lung cancer. " 04/30/2004 - "The high formation of BPDE-N(2)-dG adducts in bronchial epithelial cells and investigations showing that the profile of mutations induced by BPDE in these cells is similar to that seen in the p53 gene isolated from human lung tumors implicates benzo[a]pyrene as important carcinogen in tobacco-induced lung cancer in human beings."
4.	Neoplasms (Cancer) 04/30/2004 - "The high formation of BPDE-N(2)-dG adducts in bronchial epithelial cells and investigations showing that the profile of mutations induced by BPDE in these cells is similar to that seen in the p53 gene isolated from human lung tumors implicates benzo[a]pyrene as important carcinogen in tobacco-induced lung cancer in human beings."

Related Drugs and Biologics

1.	Smoke
2.	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide
3.	Biomarkers (Surrogate Marker)
4.	DNA (Deoxyribonucleic Acid)
5.	Carcinogens
6.	Benzo(a)pyrene
7.	Adenine