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N-methylglycinamide
Also Known As:
sarcosinamide
Networked:
5
relevant articles (
0
outcomes,
0
trials/studies)
Bio-Agent Context: Research Results
Amino Acids, Peptides, and Proteins: 1
Amino Acids: 30675
Glycine: 5151
N-substituted Glycines
Sarcosine: 281
N-methylglycinamide: 5
Related Diseases
1.
Glioma (Gliomas)
07/01/1989 - "
The cytotoxicity of a 2-chloroethylnitrosourea analog of sarcosinamide in the SK-MG-1 human glioma cell line as a possible indicator for transport.
"
05/15/1990 - "
Transport of amino acid amide sarcosinamide and sarcosinamide chloroethylnitrosourea in human glioma SK-MG-1 cells.
"
01/01/1988 - "
The cytotoxicity of sarcosinamide chloroethylnitrosourea (SarCNU) and BCNU in primary gliomas and glioma cell lines: analysis of data in reference to theoretical peak plasma concentrations in man.
"
01/01/1992 - "
Sarcosinamide chloroethylnitrosourea (SarCNU), a new anticancer agent that exerts increased in vitro antitumor activity against gliomas as compared with BCNU (bis-chloroethylnitrosourea), the standard agent of choice, competitively inhibits sarcosinamide uptake by SK-MG-1 cells [inhibition constant (Ki) = 3.26 mM].
"
05/15/1990 - "
The transport of the amino acid amide N-[3H]sarcosinamide (methyl glycinamide) was investigated in human glioma SK-MG-1 cells.
"
2.
Primitive Neuroectodermal Tumors (PNET)
06/01/1989 - "
Ependymoblastoma tumour bearing mice were treated with sarcosinamide-CNU and compared with untreated mice with regard to tumour growth, pathological examinations and levels of phosphorylated metabolites measured by in vivo nuclear magnetic resonance spectroscopy.
"
06/01/1989 - "
The case of sarcosinamide-CNU treated ependymoblastoma.
"
3.
Neoplasms (Cancer)
01/01/1988 - "
The cytotoxicity of a new compound, sarcosinamide chloroethylnitrosourea (SarCNU), was compared with that of the clinically available bis-chloroethylnitrosourea (BCNU) in 13 primary human gliomas and in 3 human glioma cell lines using the Human Tumor Cloning Assay (HTCA).
"
4.
Lung Neoplasms (Lung Cancer)
01/01/1992 - "
Using radiolabeled N-[3H]-sarcosinamide, we determined the transport of sarcosinamide in HT-29 colon-cancer cells, in Calu-1 lung-cancer cells, and in normal foreskin DHF fibroblasts.
"
01/01/1992 - "
Lack of evidence for a high-affinity sarcosinamide carrier or a catecholamine carrier in Calu-1 lung-cancer cells, HT-29 colon-cancer cells, and DHF fibroblasts.
"
5.
Colonic Neoplasms (Colon Cancer)
01/01/1992 - "
Using radiolabeled N-[3H]-sarcosinamide, we determined the transport of sarcosinamide in HT-29 colon-cancer cells, in Calu-1 lung-cancer cells, and in normal foreskin DHF fibroblasts.
"
01/01/1992 - "
Lack of evidence for a high-affinity sarcosinamide carrier or a catecholamine carrier in Calu-1 lung-cancer cells, HT-29 colon-cancer cells, and DHF fibroblasts.
"
Related Drugs and Biologics
1.
Carmustine (FIVB)
2.
Amino Acids
3.
2- ((((2- chloroethyl)nitrosoamino)carbonyl)amino)propanamide (SarCNU)
4.
Amides
5.
Catecholamine Plasma Membrane Transport Proteins
6.
Indicators and Reagents (Reagents)
7.
Epinephrine (Adrenaline)
8.
Antineoplastic Agents (Antineoplastics)
9.
2'- (2- hydroxyphenyl)- 2'- thiazoline- 4'- carboxylic acid
10.
glycine amide