|1.||Miranda, Katrina M: 11 articles (06/2015 - 05/2002)|
|2.||Utsumi, Hideo: 9 articles (12/2015 - 08/2003)|
|3.||Wink, David A: 8 articles (06/2015 - 05/2002)|
|4.||Kemp-Harper, Barbara K: 6 articles (05/2015 - 04/2007)|
|5.||Nagasaki, Yukio: 6 articles (10/2012 - 05/2011)|
|6.||Paolocci, Nazareno: 5 articles (11/2013 - 01/2003)|
|7.||Yoshitomi, Toru: 5 articles (10/2012 - 05/2011)|
|8.||Yasukawa, Keiji: 4 articles (12/2015 - 02/2004)|
|9.||Basudhar, Debashree: 4 articles (06/2015 - 10/2013)|
|10.||Ridnour, Lisa A: 4 articles (06/2015 - 12/2005)|
05/01/1977 - "[Increase in the efficacy of tumor irradiation by using the nitroxyl free radical]."
11/25/2013 - "Thus, relatively high toxicity of nitroxyl against normal cells and its ability to induce not only apoptotic but also necrotic cell death make use of this molecule in cancer therapy questionable."
11/25/2013 - "Cytotoxicity of nitroxyl (HNO/NO-) against normal and cancer human cells."
05/01/2013 - "In the early stage of cancer, the brain tissues were characterized by a shorter-lived MRI signal than that from healthy brains (indicating a higher reducing activity for the nitroxide radical), which was accompanied by an enhancement of TTAC and MMP9 plasma levels. "
01/01/2012 - "The CC50 of the most active nitroxyl radicals with respect to cells SW480 and A431 was within 0.16-2.5 mM at the selectivity index of 3.91-7.81 in relation to cytotoxicity of the compounds for the cells of the normal L68 phenotype and tumor cells. "
05/01/2008 - "Nitroxyl radicals are very useful as exogenous spin probes for measuring free radical distribution, oxygen concentration, and redox metabolism by in vivo ESR in biological systems, using a combination of these ESR methods collectively focused on animal models of disease such as spontaneously hypertensive rat (SHR) or stroke-prone SHR (SHRSP) for the assessment of antioxidant property of drugs. "
09/01/2008 - "The effects of propofol MCT/LCT on oxidative stress in the brain of Wistar-Kyoto rats or stroke-prone spontaneously hypertensive rats were investigated by using an in vivo L-band electron spin resonance system to monitor the decay rate of 3-methoxycarbonyl-2,2,5,5-tetramethyl-pyrrolidine-1-oxyl as a nitroxyl spin probe. "
10/01/2013 - "Donors of nitroxyl (HNO) have shown promise for treatment of stroke, heart failure, alcoholism and cancer. "
01/01/1993 - "Femoral ischemia-reperfusion injury also affected spin-clearance of the nitroxide radical in the thigh. "
09/15/2001 - "Thus, neutrophil infiltration in renal ischemia/reperfusion injury may be mediated, at least in part, by the enhanced production of nitroxyl anion."
05/01/1998 - "Nitroxide radical attenuates ischaemia/reperfusion injury to the rat small intestine."
03/01/2009 - "A group of nitroxyl radicals is sensitive to redox reactions and we have investigated mechanisms of oxidative diseases, including diabetes, ischemia reperfusion injuries and gastric ulcer. "
12/01/1997 - "The effects of Cu(II) and the stable nitroxide radical 4-OH-2, 2, 6, 6-tetramethyl-piperidine-1-oxyl (TPL) on reperfusion injury following global myocardial ischemia have been studied using the isolated rat heart model in the Langendorff configuration. "
08/01/2014 - "In the present study, the antinociceptive effect of the nitroxyl (HNO) donor, Angeli's salt (Na2N2O3; AS) was investigated in models of overt pain-like behavior. "
01/01/2015 - "Therefore, the synthesized NIT nitroxide radical coupling with salicylic acid framework may represent a novel potential therapeutic candidate for treatment of chronic pain, including radicular low back pain. "
08/01/2014 - "The present study demonstrates the efficacy of a nitroxyl donor and its analgesic mechanisms in overt pain-like behavior by activating the cGMP/PKG/ATP-sensitive potassium channel (K(+)) signaling pathway."
08/01/2014 - "Nitroxyl inhibits overt pain-like behavior in mice: role of cGMP/PKG/ATP-sensitive potassium channel signaling pathway."
05/31/1996 - "The present work shows the efficacy of a stable nitroxide radical, 4-hydroxy-2, 2, 6, 6-tetramethylpiperidine-1-oxyl (TEMPOL), against heat-evoked hyperalgesia."
08/01/2013 - "This is the first study to demonstrate that nitroxyl inhibits inflammatory hyperalgesia by reducing cytokine production and activating the cGMP/PKG/ATP-sensitive K⁺ channel signaling pathway in vivo."
08/01/2013 - "Mechanical hyperalgesia was evaluated using a modified Randall and Selitto method in rats, cytokine production by ELISA and nitroxyl was determined by confocal microscopy in DAF (a cell permeable reagent that is converted into a fluorescent molecule by nitrogen oxides)-treated dorsal root ganglia neurons in culture. "
08/01/2013 - "Therefore, we addressed whether nitroxyl inhibits inflammatory hyperalgesia and its mechanism using the nitroxyl donor Angeli's salt (AS; Na₂N₂O₃). "
08/01/2013 - "The nitroxyl donor, Angeli's salt, inhibits inflammatory hyperalgesia in rats."
|1.||Adenosine Triphosphate (ATP)
|2.||Potassium Channels (Potassium Channel)
|4.||Amyloid (Amyloid Fibrils)
|8.||Nitric Oxide (Nitrogen Monoxide)
|1.||Drug Therapy (Chemotherapy)