galactose receptor

MW 42 & 48 kDa found on hepatocytes, participates in endocytosis of glycoproteins with non-reducing terminal galactose; MW 77 & 88 kDa found only on Kupffer cells, binds glycoproteins with non-reducing terminal fucose or galactose; amino acid sequence given in second source

Also Known As:

Networked: 18 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Chen, Yu-Yuan: 1 article (04/2022)
2.	Han, Hai-Hao: 1 article (04/2022)
3.	He, Xiao-Peng: 1 article (04/2022)
4.	Hu, Xi-Le: 1 article (04/2022)
5.	James, Tony D: 1 article (04/2022)
6.	Li, Jia: 1 article (04/2022)
7.	Pan, Zhi-Qiang: 1 article (04/2022)
8.	Xie, Dong-Hao: 1 article (04/2022)
9.	Xie, Hai-Na: 1 article (04/2022)
10.	Zang, Yi: 1 article (04/2022)

Related Diseases

1.	Lung Neoplasms (Lung Cancer) 12/20/2018 - "In cytotoxicity studies, GEM-FGONS demonstrated time- and dose-dependent high toxicities on fucose-receptor-overexpressing MDA-MB-231 human breast cancer cells and A549 human lung cancer cells. "
2.	Infections 12/01/1992 - "Finally, our study indicates that different cell membrane molecules are not equally efficient in allowing infection of human cells because targeting of the transferrin, high density lipoprotein and galactose receptors, as well as that of various membrane glycoconjugates, by murine ecotropic retroviruses did not lead to the establishment of a proviral state."
3.	Breast Neoplasms (Breast Cancer) 12/20/2018 - "In cytotoxicity studies, GEM-FGONS demonstrated time- and dose-dependent high toxicities on fucose-receptor-overexpressing MDA-MB-231 human breast cancer cells and A549 human lung cancer cells. "
4.	Neoplasms (Cancer) 10/01/2020 - "The abundant expression of galactose receptor on tumor cells facilitated the positive targeting and cellular uptake efficiency of PGCA@PA NPs, after which PA could be synchronously released in company with the intracellular disassembly of PGCA NPs, due to the detaching of CA moieties under acidic microenvironment in endo/lysosomal compartment. " 12/20/2018 - "Designing Two-Dimensional Nanosheets for Improving Drug Delivery to Fucose-Receptor-Overexpressing Cancer Cells." 11/07/2018 - "Syntheses and anti-cancer activity of CO-releasing molecules with targeting galactose receptors." 04/01/2007 - "By deleting the ribose/galactose receptor, bacterial accumulation localized to tumor quiescence and had a greater individual effect on inducing apoptosis than wild-type S. " 01/01/2017 - "Herein, galactose-grafted, ultra-pH-sensitive, ortho ester-based drug carriers, which can respond to both extracellular and intracellular pH, and target to galactose-receptors in cell membrane, have been successfully constructed by facile method, therefore achieving stepwise targeting to microenvironment of liver cancer and then enhancing drug accumulation and tumor inhibition. "
5.	Liver Neoplasms (Liver Cancer) 04/19/2022 - "The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone." 01/01/2017 - "Herein, galactose-grafted, ultra-pH-sensitive, ortho ester-based drug carriers, which can respond to both extracellular and intracellular pH, and target to galactose-receptors in cell membrane, have been successfully constructed by facile method, therefore achieving stepwise targeting to microenvironment of liver cancer and then enhancing drug accumulation and tumor inhibition. " 01/01/2017 - "Herein, galactose-grafted, ultra-pH-sensitive drug carriers (POEAd-g-LA-DOX micelles), which could respond to both extracellular and intracellular pH, and combine with galactose-receptors in cell membrane, were constructed by a facile method, therefore achieving: (i) remaining stable at pH 7.4; (ii) responding to tumoral extracellular pH following gradually larger nanoparticles (NPs); (iii) conjugating receptors in the cell membrane of liver cancer through surface galactose-ligands of micelles; (iv) being sensitive to tumoral intracellular pH following further swelling for rapid drug release. " 06/01/1991 - "N-(2-Hydroxypropyl)methacrylamide (HPMA) copolymers containing doxorubicin (DOX) and galactosamine can be targeted to the hepatocyte galactose receptor for organ-specific chemotherapy of primary and metastatic liver cancer. "

Related Drugs and Biologics

1.	Transferrin (beta 2 Transferrin)
2.	HDL Lipoproteins
3.	Glycoconjugates
4.	Galactose (Galactopyranose)
5.	Galactosamine
6.	Doxorubicin (Adriamycin)
7.	N-(2-hydroxypropyl)methacrylamide
8.	hydroxypropyl methacrylate
9.	Mannose-Binding Lectin (Mannan-Binding Lectin)
10.	Antisense Oligonucleotides

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Intravenous Administration
3.	Microspheres (Microsphere)
4.	Immunotherapy