piroximone

10/01/1987 - "Thus, piroximone may prove useful in the long-term management of chronic cardiac failure. "
11/01/1987 - "Thus, long-term treatment with piroximone was not associated with an improvement in maximal and submaximal exercise capacity in patients with congestive heart failure. "
01/01/1984 - "The pharmacological profile revealed by these and other studies suggests that MDL 19205 should be useful in the clinical treatment of congestive heart failure."
10/01/1995 - "[Acute hemodynamic effects of piroximone i.v. in patients with severe heart failure]."
05/01/1994 - "Effects of piroximone on the right ventricular function in severe heart failure patients."

01/01/1986 - "Cardiac index was increased less by SN (15%) than piroximone (48%) (p less than 0.001), and stroke work index significantly enhanced only by piroximone (p less than 0.001). "
05/01/1987 - "The increase in stroke work index with a concomitant decrease in left ventricular filling pressure indicates an improvement in systolic performance after treatment with piroximone. "

11/01/1987 - "Seven of the 10 patients completed 12 weeks of therapy with piroximone; one patient withdrew after 8 weeks because of deterioration in clinical status; one developed severe ventricular arrhythmias and died after 5 days of treatment; and a drug-induced hepatitis was documented in one subject at 4 weeks. "

02/01/1995 - "Pharmacokinetics of piroximone after oral and intravenous administration to patients with renal insufficiency."
02/01/1995 - "The pharmacokinetics of piroximone (PI) were determined in patients with renal failure (inulin clearance less than 50 ml min-1 per 1.73 m2) using two protocols: (a) 10 patients received a single i.v. infusion of 0.5 mg kg-1 PI and the data were compared with those from seven healthy subjects receiving the same regimen; (b), a single oral dose of either 25 or 50 mg PI was given to 20 patients. "

03/01/1993 - "Serial assessment of hemodynamics, plasma piroximone levels, and ventricular ectopic beats was performed. "