|1.||da Silveira, Nayara Santos: 1 article (01/2014)|
|2.||de Oliveira-Silva, Grasielle Lopes: 1 article (01/2014)|
|3.||Bispo-da-Silva, Luiz Borges: 1 article (01/2014)|
|4.||Prado, Ligia Carolina da Silva: 1 article (01/2014)|
|5.||Lamanes, Bianca de Freitas: 1 article (01/2014)|
|6.||Wang, Dongdong: 1 article (10/2012)|
|7.||Tian, Shuge: 1 article (10/2012)|
|8.||Yu, Qian: 1 article (10/2012)|
|9.||Upur, Halmuart: 1 article (10/2012)|
|10.||Anwar, Muhammad M: 1 article (07/2012)|
|1.||Body Weight (Weight, Body)
07/01/2012 - "Pulegone was administered by gavage at 0, 75, or 150 mg/kg body weight to female rats for 4 and 6 weeks. "
03/31/1998 - "Pulegone was given orally by gavage to groups of 28 SPF Wistar rats at dosage levels of 0 or 160 mg/kg body weight per day for 28 days. "
08/01/2011 - "2-YEAR STUDY IN MICE: Groups of 50 male and 50 female mice were administered 0, 37.5, 75, or 150 mg pulegone/kg body weight in corn oil by gavage, 5 days per week for 105 weeks. "
08/01/2011 - "2-YEAR STUDY IN RATS: Groups of 50 male and 50 female rats were administered 0, 18.75 (males only), 37.5, 75, or 150 (females only) mg pulegone/kg body weight in corn oil by gavage, 5 days per week for up to 104 weeks. "
08/01/2011 - "3-MONTH STUDY IN MICE: Groups of 10 male and 10 female mice were administered 0, 9.375, 18.75, 37.5, 75, or 150 mg pulegone/kg body weight in corn oil by gavage, 5 days per week for 14 weeks. "
07/01/2012 - "The present study supports the hypothesis that cytotoxicity followed by regenerative cell proliferation is the MOA for pulegone-induced urothelial tumors in female rats."
07/01/2012 - "In a 2-year bioassay, oral administration of pulegone slightly increased the urothelial tumor incidence in female rats. "
10/01/1987 - "Intraperitoneal injection of R-(+)-pulegone (pulegone), the main constituent of pennyroyal oil, to ddY mice caused extensive liver injury as characterized by an increase in serum glutamic pyruvic transaminase (GPT) activity and centrilobular necrosis of hepatocytes. "
09/01/1987 - "The formation of a toxic metabolite is apparently mediated by cytochromes P-450 of the phenobarbital class inasmuch as phenobarbital pretreatment of mice increases, whereas beta-naphthoflavone pretreatment decreases, the extent of hepatic necrosis caused by pulegone. "
|4.||Dehydration (Water Stress)
09/01/1987 - "Menthofuran was identified as a proximate toxic metabolite of (R)-(+)-pulegone, and investigations with (R)-(+)-pulegone-d6 and 18O2 strongly indicate that menthofuran is formed by a sequence of reactions that involve: 1) oxidation of an allylic methyl group, 2) intramolecular cyclization to form a hemiketal, and 3) dehydration to form the furan."
06/15/2001 - "Microsomal preparations, from the oil gland secretory cells of a high (+)-menthofuran-producing chemotype of Mentha pulegium, transform (+)-pulegone to (+)-menthofuran in the presence of NADPH and molecular oxygen, implying that menthofuran is synthesized by a mechanism analogous to that of mammalian liver cytochrome P450s involving the hydroxylation of the syn-methyl group of (+)-pulegone, spontaneous intramolecular cyclization to the hemiketal, and dehydration to the furan. "
|1.||Corn Oil (Oil, Corn)