cyclaradine-5'-methoxyacetate

used in treatment of herpes simplex encephalitis; structure in first source

Also Known As:

Acetic acid, methoxy-, (4-(6-amino-9H-purin-9-yl)-2,3-dihydroxycyclopentyl)methyl ester, (1alpha,2beta,3alpha,4alpha)-(+-)-

Networked: 1 relevant articles (1 outcomes, 0 trials/studies)

1.	Encephalitis (Encephalitis, Rasmussen) 10/01/1983 - "Comparison of the efficacy of vidarabine, its carbocyclic analog (cyclaradine), and cyclaradine-5'-methoxyacetate in the treatment of herpes simplex virus type 1 encephalitis in mice."
2.	Drug-Related Side Effects and Adverse Reactions 10/01/1983 - "Drug toxicity (measured by weight loss) was not detected in mice treated with cyclaradine or cyclaradine-5'-methoxyacetate at 750 mg/kg per day, whereas severe toxicity (weight loss of greater than or equal to 3 g) was observed in mice treated with vidarabine at an equivalent dose level. "
3.	Weight Loss (Weight Reduction) 10/01/1983 - "Drug toxicity (measured by weight loss) was not detected in mice treated with cyclaradine or cyclaradine-5'-methoxyacetate at 750 mg/kg per day, whereas severe toxicity (weight loss of greater than or equal to 3 g) was observed in mice treated with vidarabine at an equivalent dose level. "
4.	Infections 10/01/1983 - "The relative therapeutic effects of vidarabine (9-beta-D-arabinofuranosyladenine), cyclaradine (the adenosine deaminase-resistant carbocyclic analog of vidarabine), and cyclaradine-5'-methoxyacetate in the parenteral treatment of systemic herpes simplex virus type 1 infections in Swiss mice were determined. "

1.	Vidarabine (Vira-A)
2.	carbocyclic arabinosyladenine
3.	Therapeutic Uses
4.	Adenosine Deaminase