panipenem

synthetic cpd; structure given in first source

Also Known As:

6-(1-hydroxyethyl)-2-(1--acetimidoylpyrrolidin-3-ylthio)-1-carbapen-2-em-3-carboxylic acid; CS 533; CS-533; carbapenem RS 533; carbapenem RS-533; 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid, 6-(1-hydroxyethyl)-3-((1-(1-iminoethyl)-3-pyrrolidinyl)thio)-7-oxo-, (5R-(3(S*),5alpha,6alpha(R*)))-

Networked: 25 relevant articles (4 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Tajima, Naoyuki: 3 articles (01/2006 - 02/2005)
2.	Mizutani, Takaharu: 2 articles (12/2008 - 01/2007)
3.	Ishizuka, Hitoshi: 2 articles (01/2006 - 11/2005)
4.	Naganuma, Hideo: 2 articles (01/2006 - 11/2005)
5.	Cao, Y: 1 article (09/2018)
6.	He, L: 1 article (09/2018)
7.	Hu, F: 1 article (09/2018)
8.	Wang, A: 1 article (09/2018)
9.	Wang, C: 1 article (09/2018)
10.	Yin, D: 1 article (09/2018)

Related Diseases

1.	Infections 01/01/2000 - "Panipenem may be the first choice of treatment for systemic infections. " 02/01/1992 - "To conduct a basic-clinical study on newly developed panipenem/betamipron (CS-533/CS-443, PAPM/BP) against various infections in pediatrics, a study group was organized and a joint research by 17 institutions and their related hospitals was undertaken. " 02/01/1993 - "Panipenem and imipenem showed much stronger therapeutic efficacies against experimental infections with P. " 09/01/2018 - "Fosfomycin-containing regimens and meropenem-/panipenem-containing combination therapy were efficient for CR-KPN infection in neonates." 10/01/2005 - "The results of our study suggest that combination therapy of vancomycin or teicoplanin with any of S-4661, panipenem, meropenem, or imipenem would be effective for severe infections due to MRSA strains that are resistant to carbapenems."
2.	Febrile Neutropenia 01/01/2008 - "Although larger studies are necessary, panipenem appeared to be as effective and safe as cefepime for empirical monotherapy in the treatment of adult cancer patients with febrile neutropenia." 01/01/2008 - "Panipenem versus cefepime as empirical monotherapy in adult cancer patients with febrile neutropenia: a prospective randomized trial." 02/01/2013 - "Prospective randomized study of cefepime, panipenem, or meropenem monotherapy for patients with hematological disorders and febrile neutropenia."
3.	Neoplasms (Cancer) 01/01/2008 - "Although larger studies are necessary, panipenem appeared to be as effective and safe as cefepime for empirical monotherapy in the treatment of adult cancer patients with febrile neutropenia." 01/01/2008 - "Panipenem versus cefepime as empirical monotherapy in adult cancer patients with febrile neutropenia: a prospective randomized trial." 09/01/2011 - "These findings suggest that pretreatment with panipenem does not alter the pharmacokinetics of SN-38 and SN-38G, suggesting the possibility that panipenem can be used safely for cancer patients undergoing irinotecan chemotherapy."
4.	Body Weight (Weight, Body) 12/01/1998 - "VPA (50 mg/kg of body weight) or diclofenac (10 mg/kg of body weight) was administered intravenously under the steady-state plasma panipenem concentration of 4 microgram/ml, which had been achieved by a constant infusion rate. " 01/01/2006 - "The clearance of panipenem and betamipron was correlated with creatinine clearance and the volume of the distribution of panipenem was correlated with body weight. "
5.	Mitral Valve Insufficiency (Mitral Regurgitation) 03/01/2002 - "Mitral regurgitation deteriorated during the course of medical therapy, but she was discharged on 13 September, 2000 because inflammation had improved remarkably and the vegetation had disappeared after administration of penicillin G, panipenem, cefotaxime and clindamycin. "

Related Drugs and Biologics

1.	Meropenem (Merrem)
2.	Cefepime (Maxipime)
3.	Imipenem
4.	Carbapenems (Carbapenem Antibiotics)
5.	Teicoplanin
6.	Vancomycin
7.	Doripenem
8.	Clindamycin (Cleocin)
9.	N-benzoylalanine (betamipron)
10.	Penicillin G (Benzylpenicillin)

Related Therapies and Procedures

1.	Therapeutics
2.	Nephrectomy
3.	Injections
4.	Drug Therapy (Chemotherapy)
5.	Aftercare (After-Treatment)