lysylphenylalanine

cell sickling & hemoglobin S gelatin inhibitor; RN given refers to parent cpd (L)-isomer

Also Known As:

Lys-Phe; lysylphenylalanine diacetate, (L)-isomer; lysylphenylalanine dihydrochloride, (L)-isomer; lysylphenylalanine monohydrochloride, (L)-isomer

Networked: 14 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - lysylphenylalanine: 14

Experts

1.	Bhattacharya, Santanu: 2 articles (01/2020 - 01/2017)
2.	Moitra, Parikshit: 2 articles (01/2020 - 01/2017)
3.	Bashir, Mohsin: 1 article (01/2020)
4.	Kondaiah, Paturu: 1 article (01/2020)
5.	Kumar, Krishan: 1 article (01/2020)
6.	Ghosh, Surajit: 1 article (01/2020)
7.	Gupta, Varsha: 1 article (01/2020)
8.	Joseph, Manu M: 1 article (01/2020)
9.	Maiti, Kaustabh Kumar: 1 article (01/2020)
10.	Maniganda, Santhi: 1 article (01/2020)

Related Diseases

1.	Arthritis (Polyarthritis) 02/01/2015 - "Herein, we report a novel approach to conglomerate individual protein entities into a drug depot by incorporation of an amyloidogenic motif Lys-Phe-Phe-Glu (KFFE) thereby dramatically improving their systemic persistence and in turn their therapeutic efficacy in a mice model of autoimmune arthritis."
2.	Pathologic Processes 01/12/2001 - "Due to the importance of cathepsin D in several physiological and pathological processes, we took the peptide containing kallistatin RSL sequence, Abz-Ala-Ile-Lys-Phe-Phe-Ser-Arg-Gln-EDDnp, as a reference substrate for a systematic specificity study of S3 to S3' protease subsites (EDDnp=N-[2,4-dinitrophenyl]-ethylenediamine and Abz=ortho-amino benzoic acid). "
3.	Amnesia (Dissociative Amnesia) 01/01/1976 - "The ACTH 4-9 analog, H-Met((O2)-Glu-His-Ph-D-Lys-Phe-OH (Or 2766), attenuates in rats CO2-induced amnesia for a one-trial passive avoidance step-through response when administered prior to the retrieval test but not when given prior to acquisition. "
4.	Sudden Infant Death (SID) 11/04/2023 - "The SID of His, Ile, Lys, Phe, Thr, Trp, and Val were 3 to 6% lower (P < 0.09) in HF than LF independent of MEblend. " 10/06/2023 - "When fed to mid-gestating sows, the SID values for Arg, His, Lys, Phe, Cys, Gly, Ser, and Tyr in SBM 1 were lower than in SBM 4 and 5 (P < 0.05), whereas SID for Leu from SBM 5 was higher than in SBM 1 and 4 (P < 0.05). " 06/04/2018 - "An interaction (P < 0.05) was also observed on SID of Arg, His, Leu, Lys, Phe, Thr, Val, Asp, Cys, Glu, and Ser. " 10/01/2005 - "The SID of Lys, Phe, and Thr were higher (P < 0.05) in low-phytate corn than in normal corn. "
5.	Neoplasms (Cancer) 10/19/2011 - "As a result, the Lys-Phe substituted anthraquinones are poorly cytotoxic but still able to promote a senescence mechanism in cancer cells. " 01/02/2020 - "Gold nanoparticles (AuNPs) capped with a natural pH-responsive short tripeptide (Lys-Phe-Gly or KFG) sequence are presented herein for significant intracellular delivery of an anti-cancer drug, doxorubicin (DOX). " 04/01/2009 - "In addition, a novel peptide with a Lys-Phe-amide C-terminus was identified and de novo sequenced directly from the Cancer borealis hemolymph sample. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	phenylalanylglutamate
3.	Peptides (Polypeptides)
4.	hydroxide ion
5.	Benzoic Acid (Potassium Benzoate)
6.	Peptide Hydrolases (Proteases)
7.	Cathepsin D
8.	arginyl-glutamine
9.	kallistatin
10.	ethylenediamine (ethylenediamine dihydroiodide)