1,2-dibromo-2,4-dicyanobutane

12/01/2000 - "Improved screening for methyldibromoglutaronitrile allergy."
01/01/2006 - "The results of our study confirmed observations of other authors that allergy to preservatives present in numerous industrial products, especially Euxyl K 400, is still a growing problem. "
05/01/2011 - "This review summarizes the history, epidemiology, and management of contact allergy to Euxyl K 400. "
05/01/2011 - "Although Euxyl K 400 initially appeared to have low sensitizing potential, increased prevalence of contact allergy to Euxyl K 400 led to regulatory intervention. "
11/01/2010 - "in Europe, methyldibromoglutaronitrile (MDGN) was banned because of excessive rates of contact allergy. "

01/01/2004 - "Methyldibromoglutaronitrile in rinse-off products causes allergic contact dermatitis: an experimental study."
02/01/2006 - "Connubial allergic contact dermatitis to Euxyl K 400."
06/01/2005 - "Allergic contact dermatitis from methyldibromoglutaronitrile."
01/01/2001 - "Allergic contact dermatitis due to methyldibromo glutaronitrile in Euxyl K 400 in an ultrasonic gel."
09/01/1996 - "Occupational allergic contact dermatitis caused by Euxyl K 400."

02/01/1996 - "From 15 May to 15 December 1994, 2943 patients suspected of having contact dermatitis (1955 women, 988 men) were patch tested with methyldibromoglutaronitrile 0.3%, 0.1% and 0.05% pet. "
01/01/1992 - "Contact dermatitis from Euxyl K 400 in cucumber eye gel."
08/01/1991 - "2057 consecutive patients with contact dermatitis were patch tested with Euxyl K 400 2.5% pet. "
11/01/1996 - "In The Netherlands, Italy, and Germany, the prevalence of allergy to Euxyl K 400 has risen in the past 4 years and is currently 2% to 4% in patients suspected of having contact dermatitis. "
07/01/2021 - "Patch Testing to Methyldibromoglutaronitrile/Phenoxyethanol: North American Contact Dermatitis Group Experience, 1994-2018."

12/01/2007 - "Repeated open application tests with methyldibromoglutaronitrile in dermatitis patients with and without hypersensitivity to methyldibromoglutaronitrile."
01/01/2006 - "This study aimed to investigate in methyldibromoglutaronitrile (MDBGN) allergic patients whether skin with previous allergic dermatitis from MDBGN showed an augmented response on re-exposure by both a patch test challenge and a use test with a liquid soap preserved with MDBGN. "
11/01/1996 - "Because the causative products usually give false-negative reactions, the allergen, methyldibromoglutaronitrile, should be tested in all patients suspected of having cosmetic dermatitis and in those with perianal dermatitis. "

06/01/2010 - "NTP technical report on the toxicology and carcinogenesis studies of 1,2-dibromo-2,4-dicyanobutane (CAS No. 35691-65-7) in F344/N rats and B6C3F1 mice (dermal studies)."