|1.||Gábelová, Alena: 3 articles (10/2011 - 01/2002)|
|2.||Machala, Miroslav: 2 articles (10/2011 - 06/2009)|
|3.||Milcová, Alena: 2 articles (10/2011 - 06/2009)|
|4.||Trilecová, Lenka: 2 articles (10/2011 - 06/2009)|
|5.||Topinka, Jan: 2 articles (10/2011 - 06/2009)|
|6.||Mesárošová, Monika: 1 article (10/2011)|
|7.||Hrubá, Eva: 1 article (10/2011)|
|8.||Marvanová, Soňa: 1 article (10/2011)|
|9.||Schmuczerová, Jana: 1 article (10/2011)|
|10.||Vondráček, Jan: 1 article (10/2011)|
06/01/2009 - "Our recent study showed that the liver carcinogens 7H-dibenzo[c,g]carbazole (DBC) and 5,9-dimethyldibenzo[c,g]carbazole (DiMeDBC), but not the sarcomagen N-methyldibenzo[c,g]carbazole (N-MeDBC), induced several cellular events associated with tumor promotion in WB-F344 cells, an in vitro model of liver oval cells [J. "
|2.||Hepatocellular Carcinoma (Hepatoma)
10/01/2011 - "The goal of this study was to investigate the genotoxicity of 7H-dibenzo[c,g]carbazole (DBC), a ubiquitous environmental pollutant, and its methyl derivatives, 5,9-dimethylDBC (DiMeDBC), a strict hepatocarcinogen, and N-methylDBC (N-MeDBC), a specific sarcomagen in human hepatoma HepG2 cells, and to infer potential mechanisms underlying the biological activity of particular carcinogen. "
10/01/2011 - "Our data clearly demonstrated differences in the mechanisms involved in the biological activity of DiMeDBC and N-MeDBC in human hepatoma cells; the genotoxicity of these DBC derivatives is closely related to CYP1A1/2 expression."
10/01/2011 - "A significant increase in DNA strand breaks following incubation of exposed cells with a repair-specific endonuclease (Fpg protein) suggested that either oxidative DNA damage or unstable DNA-adducts might underlie DiMeDBC genotoxicity in human hepatoma cells. "
|3.||Chromosome Aberrations (Chromosome Abnormalities)
01/01/2002 - "Occasionally, B[a]P induced chromosomal aberrations and micronuclei, and diMeDBC induced micronuclei, but not chromosomal aberrations. "
01/01/2002 - "After B[a]P treatment, we found a reduction in DNA breaks and chromosomal aberrations; after treatment with diMeDBC, we observed a reduction in DNA breaks. "
|4.||Cytochrome P-450 CYP1A1 (CYP1A1)
|6.||DNA (Deoxyribonucleic Acid)