cianergoline

RN given refers to (8beta)-isomer; structure given in first source

Also Known As:

2-CMEBP; 2-cyano-3-(6-methylergolin-8 beta-yl)propionamide; 6-methyl-8-(2-cyano)propionamidoergoline; ergoline 3355-1057; Ergoline-8-propanamide, alpha-cyano-6-methyl-, (8beta)-

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Ergot Alkaloids: 208
    - Ergolines: 109
      - cianergoline: 2
- Fused-Ring Heterocyclic Compounds
  - 4 or More Rings Heterocyclic Compounds
    - Ergolines: 109
      - cianergoline: 2

Related Diseases

1.	Ocular Hypotension 01/01/1987 - "Topically administered cianergoline (0.022-0.22 mg) produced dose-related, unilateral ocular hypotension in normal but not in SX rabbits. "
2.	Ocular Hypertension (Glaucoma, Suspect) 01/01/1987 - "Cianergoline (0.22mg) suppressed ocular hypertension induced by waterloading in rabbits, and this effect was antagonized by metoclopramide, a relatively selective DA2 antagonist. " 01/01/1987 - "Cianergoline, a new ergoline derivative, was tested for: 1) ocular hypotensive activity in normal and sympathectomized (SX) rabbits and in normal capuchin monkeys, 2) inhibition of induced ocular hypertension by waterloading in rabbits and 3) suppression of contractions of the cat nictitating membrane (CNM) elicited by electrical stimulation of sympathetic nerves and by intraarterial (i.a.) injection of norepinephrine (NE). "
3.	Nausea 01/01/1985 - "3 out of 10 patients in the cianergoline group complained of nausea. "
4.	Essential Hypertension 01/01/1985 - "Effects of the dopaminergic agonist cianergoline on blood pressure, the renin-angiotensin-aldosterone axis and the sympathetic nervous system in patients with essential hypertension." 01/01/1985 - "The findings indicate that the new dopaminergic agonist cianergoline exerts only a mild blood pressure lowering effect in patients with essential hypertension and does not modify the release of prolactin, lipid metabolism or the basal activity or postural responsiveness of the renin-angiotensin-aldosterone axis and of the sympathetic nervous system."

Related Drugs and Biologics

1.	Dopamine Agonists (Dopamine Agonist)
2.	Renin
3.	Prolactin
4.	Norepinephrine (Noradrenaline)
5.	Metoclopramide (Reglan)
6.	Ergolines
7.	Angiotensins
8.	Aldosterone