|1.||Lee, Inchul: 2 articles (07/2008 - 06/2003)|
|2.||Shaik, Imam H: 1 article (12/2011)|
|3.||Mehvar, Reza: 1 article (12/2011)|
|4.||Kim, Young C: 1 article (07/2008)|
|5.||Bae, Soo K: 1 article (07/2008)|
|6.||Shin, Wan G: 1 article (07/2008)|
|7.||Ahn, Choong Y: 1 article (07/2008)|
|8.||Jung, Young S: 1 article (07/2008)|
|9.||Lee, Myung G: 1 article (07/2008)|
|10.||Gastonguay, Marc R: 1 article (12/2003)|
|2.||Acute Kidney Injury (Acute Renal Failure)
06/01/2003 - "The purpose of this study is to report the changes of CYP2E1, CYP1A2, CYP2B1/2, CYP2C11, CYP3A23, and CYP3A2 expression and pharmacokinetics and tissue distribution of chlorzoxazone (CZX) and 6-hydroxychlorzoxazone (OH-CZX) in rats with acute renal failure induced by uranyl nitrate (U-ARF), and the role of CYP3A23 and CYP3A2 in the formation of OH-CZX in rats with U-ARF. "
|3.||Kidney Diseases (Kidney Disease)
12/01/2003 - "The purposes of this study were (1) to describe the disposition of chlorzoxazone and 6-hydroxychlorzoxazone in patients with kidney disease, (2) to develop a population pharmacokinetic model including covariates that may influence the pharmacokinetic variability of both compounds, and (3) to examine the effect of covariates on the chlorzoxazone metabolic ratio. "
12/01/2003 - "Impaired 6-hydroxychlorzoxazone elimination in patients with kidney disease: Implication for cytochrome P450 2E1 pharmacogenetic studies."
12/01/2003 - "The 6-hydroxychlorzoxazone area under the plasma concentration-time curve was inversely related to CL(cr), even within the range of normal renal function, resulting in chlorzoxazone metabolic ratio values that were substantially higher in subjects with kidney disease. "
12/01/2003 - "Although cytochrome P450 (CYP) 2E1 activity, as estimated by 6-hydroxychlorzoxazone formation clearance, was not affected by kidney disease, the chlorzoxazone metabolic ratio was substantially elevated in these subjects. "
12/01/2011 - "Here, we investigated the effects of 1 h of partial ischemia, followed by 3 (IR3) or 24 (IR24) h of in vivo reperfusion, on the in vivo, isolated perfused rat liver (IPRL), and microsomal disposition of chlorzoxazone (CZX) and its cytochrome P450 2E1 (CYP2E1)-mediated metabolite, 6-hydroxychlorzoxazone (HCZX), in rats. "
|2.||Cytochrome P-450 CYP2E1 (CYP2E1)
|3.||Cytochrome P-450 CYP1A2 (CYP1A2)
|4.||Cytochrome P-450 CYP2B1 (PROD)
|6.||rat CYP3A23 protein
|8.||Cytochrome P-450 Enzyme System (Cytochrome P450)