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deoxynucleotide 3'-phosphatase

catalyzes the removal of 3'-phosphates from strand breaks

Also Known As:

DNA 3'-phosphatase; TPP1 (three prime phosphatase) protein, S cerevisiae; three prime phosphatase 1, S cerevisiae

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Esterases: 1574
      - Phosphoric Monoester Hydrolases: 7477
        Nucleotidases: 50
        deoxynucleotide 3'-phosphatase: 2

Experts

1.	Ashworth, Alan: 1 article (10/2013)
2.	El Gendy, Mohamed A M: 1 article (10/2013)
3.	Foley, Edan: 1 article (10/2013)
4.	Ghosh, Sunita: 1 article (10/2013)
5.	Lord, Christopher J: 1 article (10/2013)
6.	Mendes-Pereira, Ana M: 1 article (10/2013)
7.	Mereniuk, Todd R: 1 article (10/2013)
8.	Weinfeld, Michael: 1 article (10/2013)
9.	Caldecott, Keith W: 1 article (08/2012)
10.	Gilmore, Edward C: 1 article (08/2012)

Related Diseases

1.	Inborn Genetic Diseases (Disease, Hereditary) 08/01/2012 - "Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA strand break repair protein with DNA 5'-kinase and DNA 3'-phosphatase activity. "
2.	Seizures (Absence Seizure) 08/01/2012 - "Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA strand break repair protein with DNA 5'-kinase and DNA 3'-phosphatase activity. "
3.	Microcephaly 08/01/2012 - "Microcephaly with early-onset, intractable seizures and developmental delay (MCSZ) is a hereditary disease caused by mutations in polynucleotide kinase/phosphatase (PNKP), a DNA strand break repair protein with DNA 5'-kinase and DNA 3'-phosphatase activity. "
4.	Colonic Neoplasms (Colon Cancer) 10/01/2013 - "In HCT116 colon cancer cells, the loss of PTEN is accompanied by an increased background level of DNA double-strand breaks, which accumulate in the presence of an inhibitor of PNKP DNA 3'-phosphatase activity. "

Related Drugs and Biologics

1.	DNA (Deoxyribonucleic Acid)
2.	A-Form DNA (A-DNA)
3.	Proteins (Proteins, Gene)
4.	Polynucleotide 5'-Hydroxyl-Kinase (Kinase, Polynucleotide)
5.	Phosphoric Monoester Hydrolases (Phosphatases)