|1.||Du-Cuny, Lei: 2 articles (01/2015 - 03/2010)|
|2.||Min, Do Sik: 2 articles (01/2015 - 12/2014)|
|3.||Zhang, Shuxing: 2 articles (01/2015 - 03/2010)|
|4.||Choi, Kang-Yell: 2 articles (01/2015 - 12/2014)|
|5.||Meuillet, Emmanuelle J: 2 articles (01/2015 - 03/2010)|
|6.||Park, Mi Hee: 2 articles (01/2015 - 12/2014)|
|7.||Newton, Alexandra C: 2 articles (01/2014 - 06/2011)|
|8.||Rottapel, Robert: 2 articles (09/2012 - 04/2007)|
|9.||Chen, Grace: 2 articles (09/2012 - 04/2007)|
|10.||Saito, Masaaki: 2 articles (04/2012 - 03/2012)|
|1.||Breast Neoplasms (Breast Cancer)
01/01/2013 - "We have performed functional analysis of six non-hotspot AKT1 pleckstrin homology domain mutants identified in recent large-scale breast cancer sequencing studies. "
01/01/2015 - "Novel inhibitors induce large conformational changes of GAB1 pleckstrin homology domain and kill breast cancer cells."
07/01/2008 - "One of the genes shown to be down-regulated in breast tumors compared to normal breast tissue was the PHLDA1 (Pleckstrin homology-like domain, family A, member 1). "
04/01/2011 - "Signal-transducing adaptor protein (STAP)-2 is a recently identified adaptor protein that contains Pleckstrin homology and Src homology 2-like domains, and is also known to be a substrate of breast tumor kinase (Brk). "
11/01/2007 - "In a previous study, using differential display reverse transcriptase-PCR (DDRT-PCR) we showed that down-regulation of the PHLDA1 (pleckstrin homology-like domain, family A, member 1; also named TDAG51) mRNA was down-regulated in breast tumors compared with normal breast tissue. "
01/01/2015 - "In the present study, we aim to target the pleckstrin homology (PH) domain of GAB1 for cancer treatment. "
05/01/2015 - "We detected in-frame duplications affecting the pleckstrin-homology domain of AKT1 in more than 60% of the tumors occurring in girls under 15 years of age. "
01/01/2015 - "The pleckstrin homology domain (PH) of PLD1 itself promotes degradation of HIF-1α, then accelerates EGFR endocytosis via upregulation of rabaptin-5 and suppresses tumor progression. "
01/01/2015 - "Recent findings suggest decreasing PHLDA1 (pleckstrin-homologylike domain family A, member1) expression plays a significant role in inhibiting cell migration and tumor invasion. "
01/01/2015 - "The Pleckstrin and Sec7 domain-containing (PSD) gene has been recently found to participate in the progression of several types of cancer. "
04/01/2011 - "In a patient with a heterozygous mutation in RUNX1, we have described decreased platelet pleckstrin phosphorylation and protein kinase C- (PKC-, gene PRKCQ) associated with thrombocytopenia, impaired platelet aggregation, and dense granule secretion. "
08/01/1999 - "In this study, we investigated the role of the pleckstrin homology (PH) domain of the Wiskott-Aldrich syndrome protein (WASP) in the regulation of actin cytoskeleton, which is defective in patients with Wiskott-Aldrich syndrome (WAS) and X-linked thrombocytopenia (XLT). "
02/01/2004 - "We have reported data on a patient with thrombocytopenia and impaired receptor-mediated aggregation, phosphorylation of pleckstrin (a protein kinase C [PKC] substrate), and activation of the GPIIb-IIIa complex. "
01/01/2007 - "We have reported on a patient with thrombocytopenia, impaired platelet aggregation, secretion, phosphorylation of pleckstrin and myosin light chain (MLC), and GPIIb-IIIa activation, associated with a heterozygous mutation in transcription factor CBFA2 (core binding factor A2, RUNX1 or AML1). "
|4.||Hypertension (High Blood Pressure)
09/02/2014 - "PLEKHA7 (pleckstrin homology domain containing family A member 7) has been found in multiple studies as a candidate gene for human hypertension, yet functional data supporting this association are lacking. "
06/01/2010 - "Four loci-ATP2B1 (ATPase, Ca(++) transporting, plasma membrane 1), CSK (c-src tyrosine kinase), CYP17A1 (cytochrome P450 17A1) and PLEKHA7 (pleckstrin homology domain-containing family A member 7)-were associated with blood pressure and hypertension in the Korean population."
02/01/2012 - "Diabetes induced tissue-specific changes in messenger RNAs expression of the following selected genes, which were restored by telmisartan treatment: PPARγ, PPARδ, PPARγ coactivator 1α, adiponectin, adiponectin receptor 1, adiponectin receptor 2, phosphotyrosine binding domain and a pleckstrin homology domain-containing adaptor protein, adenosine monophosphate kinase, and glucose translocator 4. Telmisartan blunted the development of hypertension, insulin resistance, and diabetes in prediabetic Cohen-Rosenthal diabetic hypertensive rats through pleiotropic activity, involving specific gene regulation of target organs."
|5.||Wiskott-Aldrich Syndrome (Syndrome, Wiskott-Aldrich)
|1.||Messenger RNA (mRNA)
|2.||Wiskott-Aldrich Syndrome Protein
|3.||RNA-Directed DNA Polymerase (Reverse Transcriptase)
|5.||Proteins (Proteins, Gene)
|6.||leucine-rich repeat proteins
|7.||Proto-Oncogene Proteins c-akt (Protein Kinase B)
|8.||rho guanine nucleotide exchange factors (rhoGEF)
|9.||Guanine Nucleotide Exchange Factors (Guanine Nucleotide Exchange Factor)