|1.||Moro, Stefano: 1 article (03/2009)|
|2.||Palumbo, Manlio: 1 article (03/2009)|
|3.||Menegazzo, Ileana: 1 article (03/2009)|
|4.||Richter, Sara N: 1 article (03/2009)|
|5.||Nadai, Matteo: 1 article (03/2009)|
|6.||Palumbo, M: 1 article (10/2001)|
|7.||Gatto, B: 1 article (10/2001)|
|8.||Richter, S: 1 article (10/2001)|
|9.||Moro, S: 1 article (10/2001)|
|10.||Capranico, G: 1 article (10/2001)|
10/15/2001 - "The guanine-alkylating ability of clerocidin suggests an unprecedented mechanism of topo II poisoning, according to which the enzyme renders the drug reactive toward DNA by distorting the double-helical structure of the nucleic acid at the cleavage site."
03/07/2009 - "Clerocidin is a complex natural molecule which induces DNA damage both directly and through irreversible/reversible poisoning of prokaryotic/eukaryotic topoisomerases II. By analysis of clerocidin reactivity towards adenine and thymine bases, we were able to fully characterize and compare the unique direct reactivity of clerocidin towards the four DNA bases, both in solution and in the DNA context. "
|1.||DNA (Deoxyribonucleic Acid)
|4.||Type II DNA Topoisomerases (Topoisomerase II)
|6.||trioctyl phosphine oxide (TOPO)