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4- (2- (5,6,7,8- tetrahydro- 5,5,8,8- tetramethyl- 2- naphthalenyl)- 1- propenyl)benzoic acid

RN refers to (E)-isomer; structure given in first source
Also Known As:
AGN 191183; AGN-191183; Ro 13-7410; TTNPB; arotinoid Ro-137410
Networked: 20 relevant articles (1 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Germain, Pierre: 2 articles (09/2007 - 12/2004)
2. Kammerer, Sabrina: 2 articles (09/2007 - 12/2004)
3. Gronemeyer, Hinrich: 2 articles (09/2007 - 12/2004)
4. Lamph, William W: 2 articles (03/2006 - 05/2002)
5. Brown, Powel H: 2 articles (03/2006 - 05/2002)
6. Wu, Kendall: 2 articles (03/2006 - 05/2002)
7. Nishi, Y: 2 articles (12/2001 - 08/2000)
8. Yanase, T: 2 articles (12/2001 - 08/2000)
9. Mu, Y M: 2 articles (12/2001 - 08/2000)
10. Takayanagi, R: 2 articles (12/2001 - 08/2000)

Related Diseases

1. Skin Diseases
2. Breast Neoplasms (Breast Cancer)
11/21/2011 - "4-Hydroxybenzyl modification of the highly teratogenic retinoid, 4-[(1E)-2-(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthalenyl)-1-propen-1-yl]benzoic acid (TTNPB), yields a compound that induces apoptosis in breast cancer cells and shows reduced teratogenicity."
09/01/1998 - "The present study aims to characterize the effect which four retinoids (TTNPB, 9-cis-RA, LGD 1069, 4-HPR) with distinct RAR/RXR binding properties induced on various in vitro and in vivo mouse and human breast cancer models. "
01/01/1986 - "The ability of all-trans-retinoic acid, 13-cis-retinoic acid, the free acid of etretinate (RO 10-1670), the 'arotinoid' RO 13-6298 and its free acid RO 13-7410 to affect the growth of T47D human breast cancer cells in vitro was investigated. "
08/30/2000 - "In the present study, we investigated the effects of a nuclear receptor system constituted by retinoid X receptor (RXR) and its heterodimer partner on the aromatase activity in a cultured MCF-7 human breast cancer cell line, using each selective ligand for retinoic acid receptor (RAR) (TTNPB), RXR (LG100268), PPARgamma (troglitazone), and vitamin D(3) receptor (vitamin D(3)). "
12/01/2001 - "We investigated the effects of a nuclear receptor system constituted by retinoid X receptor (RXR) and its heterodimer partner on the aromatase activity in a cultured MCF-7 human breast cancer cell line and also in human ovarian granulosa cells, using each selective ligand for retinoic acid receptor, RAR (TTNPB), retinoid X receptor, RXR (LG100268), PPARgamma (troglitazone), and vitamin D3 receptor (cholecalciferol). "
3. Squamous Cell Carcinoma (Epidermoid Carcinoma)
4. Neoplasms (Cancer)
5. Leukemia

Related Drugs and Biologics

1. Benzoic Acid (Ucephan)
2. Etretinate
3. ethyl- p- ((E)- 2- (5,6,7,8- tetrahydro- 5,5,8,8- tetramethyl- 2- naphthyl)- 1- propenyl)benzoic acid
4. Retinoids
5. Retinoic Acid Receptors (Retinoic Acid Receptor)
6. Retinoid X Receptors (Retinoid X Receptor)
7. bexarotene (LGD1069)
8. PPAR gamma
9. Calcitriol Receptors (Calcitriol Receptor)
10. Isotretinoin (Accutane)