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1,4-dihydropyridine (dihydropyridine)

Also Known As:
dihydropyridine; Lemildipine
Networked: 1102 relevant articles (88 outcomes, 183 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1. Touyz, Rhian M: 8 articles (05/2014 - 06/2005)
2. Canadian Hypertension Education Program: 8 articles (07/2011 - 01/2004)
3. Feldman, Ross D: 8 articles (07/2011 - 01/2004)
4. Yamagishi, S: 8 articles (11/2007 - 01/2003)
5. Jones, Charlotte: 7 articles (07/2011 - 06/2005)
6. Schiffrin, Ernesto L: 7 articles (07/2011 - 06/2005)
7. Herman, Robert J: 7 articles (07/2011 - 06/2005)
8. Pylypchuk, George: 7 articles (07/2011 - 06/2005)
9. Hamet, Pavel: 7 articles (07/2011 - 06/2005)
10. Campbell, Norman R C: 7 articles (07/2011 - 01/2004)

Related Diseases

1. Hypertension (High Blood Pressure)
2. Stroke (Strokes)
08/01/2005 - "In an acute stroke setting, lowering blood pressure is potentially harmful, especially if it is carried out using short-acting dihydropyridine derivatives. "
09/01/2004 - "The risk of stroke was significantly lower among subjects allocated to dihydropyridine CCBs than among those randomized to alternative drugs (odds ratio 0.90, 95% CI 0.84-0.97; P =.006), whereas the effect of non-dihydropyridine CCBs did not achieve significance (odds ratio 0.92, 95% CI 0.81-1.04). "
02/01/2003 - "This is especially true for the prevention of stroke in hypertensive patients as evidenced from the Systolic Hypertension in Europe (Syst-Eur) and Systolic Hypertension in China (Syst-China) trials with a long acting dihydropyridine CCB. "
04/01/1995 - "Decreased binding of dihydropyridine by vascular muscle cells from stroke-prone spontaneously hypertensive rats (cells that in other studies show increased Ca2+ channel function) indicates a change in channel regulation that is possibly due to a deficiency in the inactivation mechanism, consistent with our earlier electrophysiological studies reporting deficiencies in Ca(2+)-dependent inactivation in genetic hypertension. "
04/01/1995 - "To further investigate the altered function of Ca2+ channels in vascular muscle cells in hypertension, a novel fluorescently labeled dihydropyridine was used with ultrahigh-sensitivity photometry to study dihydropyridine binding sites on the surface membrane of living vascular muscle cells from stroke-prone spontaneously hypertensive rats and their normotensive controls. "
3. Angina Pectoris
4. Heart Failure
5. Proteinuria

Related Drugs and Biologics

1. Calcium
2. Calcium Channels (Calcium Channel)
3. Amlodipine (Norvasc)
4. Calcium Channel Blockers (Blockers, Calcium Channel)
5. Nifedipine (Adalat)
6. Peptidyl-Dipeptidase A (Angiotensin Converting Enzyme)
7. clevidipine
8. Isradipine (Dynacirc)
9. Nimodipine (Modus)
10. Felodipine (Agon)

Related Therapies and Procedures

1. Microspheres (Microsphere)
2. Intravenous Infusions
3. Coronary Balloon Angioplasty (Percutaneous Transluminal Coronary Angioplasty)
4. Surgical Instruments (Clip)
5. Analgesia