n-pentanoic acid (valeric acid)

RN given refers to unlabeled parent cpd

Also Known As:

valeric acid; lithium pentanoate; n-pentanoic acid, 11C-labeled; n-pentanoic acid, 11C-labeled sodium salt; n-pentanoic acid, ammonium salt; n-pentanoic acid, maganese (+2) salt; n-pentanoic acid, potassium salt; n-pentanoic acid, sodium salt; n-pentanoic acid, zinc salt

Networked: 59 relevant articles (7 outcomes, 9 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Koay, Yen Chin: 2 articles (08/2022 - 01/2020)
2.	Barman, Malin: 2 articles (01/2022 - 12/2020)
3.	Gio-Batta, Monica: 2 articles (01/2022 - 12/2020)
4.	Nayor, Matthew: 2 articles (01/2022 - 11/2020)
5.	Wold, Agnes E: 2 articles (01/2022 - 12/2020)
6.	Chen, Xinyi: 2 articles (01/2021 - 12/2020)
7.	Han, Rui: 2 articles (01/2021 - 12/2020)
8.	Nusbaum, Olivia: 2 articles (01/2021 - 12/2020)
9.	Zhu, Yong: 2 articles (01/2021 - 12/2020)
10.	Clish, Clary B: 2 articles (11/2020 - 12/2017)

Related Diseases

1.	Enteritis 07/01/2018 - "In the current study, experiments were carried out to evaluate the effect of valeric acid glycerides (GVA) on growth performance, on the morphology of the small intestinal mucosa and on protection against necrotic enteritis. " 01/01/2020 - "Efficacy of Butyric and Valeric Acid Esters in a Necrotic Enteritis Challenge Model." 07/01/2018 - "Valeric acid glyceride esters in feed promote broiler performance and reduce the incidence of necrotic enteritis."
2.	Neoplasms (Cancer) 12/16/2020 - "Further transcriptional profiling and network analyses illustrate that valeric acid affects several cancer-related pathways that may induce apoptosis. " 01/01/2022 - "Additionally, the anti-cancer function of this novel liposomal nanoparticle-modified valeric acid was found to be related to STAT3/Cyclin D1 pathway. " 12/01/2021 - "Using regression analysis, we observed that levels of Acetic and Propionic acid were associated with an increased CRC risk in the Czech cohort (Odd Ratio (OR): 1.02; 95% Confidence interval (CI): 1.00-1.03; OR: 1.29; 95% CI: 1.05-1.59, respectively), while i-Valeric and Valeric acid levels were associated with a decreased cancer risk (OR: 0.92; 95% CI: 0.86-0.99; OR: 0.67; 95% CI: 0.44-1.00). " 12/16/2020 - "Mouse models further demonstrate that systematic administration of lipid-based nanoparticle-encapsulated valeric acid significantly reduces the tumor burden and improves survival rate. " 09/29/2022 - "In this study, we theoretically and experimentally demonstrated that valeric acid (VA) was a HDAC inhibitor, and anti-cancer efficacy of VA in prostate cancer cells was also observed using either 2D or 3D culture systems. "
3.	Prostatic Neoplasms (Prostate Cancer) 09/29/2022 - "Valeric acid acts as a novel HDAC3 inhibitor against prostate cancer." 09/29/2022 - "In this study, we theoretically and experimentally demonstrated that valeric acid (VA) was a HDAC inhibitor, and anti-cancer efficacy of VA in prostate cancer cells was also observed using either 2D or 3D culture systems. "
4.	Eczema 12/31/2020 - "Valeric acid or associated microbes may have protective potential against eczema." 01/01/2022 - "In a sub-group analysis of children with eczema at 1 year of age, a higher concentration of fecal valeric acid was linked with reduced risk of their eczema remaining at 13 years of age (OR 0.2, 95% CI: 0.0-1.5), although this latter analysis did not reach statistical significance (p = 0.12). " 12/31/2020 - "High levels of valeric acid at 3 years of age were associated with low rate of eczema at 8 years of age. " 01/01/2022 - "Higher levels of fecal valeric acid may be characteristic of a protective gut microbiota and/or actively contribute to protection from eczema and food allergy." 01/01/2022 - "The concentration of fecal valeric acid at 1 year of age was inversely associated with eczema at 13 years of age (OR 0.6, 95% CI: 0.4-1.0, p = 0.049) and showed a trend for inverse association with food allergy at 13 years of age (OR 0.6, 95% CI: 0.4-1.0, p = 0.057). "
5.	Muscular Atrophy (Muscle Atrophy) 11/01/2023 - "We also demonstrated that valeric acid stimulates type IIb myofiber growth by activating the Akt/mTOR pathway via G protein-coupled receptor 43 and ameliorates dexamethasone-induced muscle atrophy. "

Related Drugs and Biologics

1.	Histone Deacetylase Inhibitors
2.	Glycerides (Acylglycerol)
3.	Lipids
4.	hexanoic acid (hexanoate)
5.	Esters
6.	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)
7.	Interleukin-17 (Interleukin 17)
8.	Glucose (Dextrose)
9.	Dexamethasone (Maxidex)
10.	Butyric Acid (Butanoic Acid)

Related Therapies and Procedures

1.	Electronic Nose
2.	Therapeutics