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PCM 4

water-soluble substance extracted from Chlorella regulararis S-50; contains 25.7% sugar, 51.5% protein & 18.7% nucleic acid

Also Known As:

PCM-4

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Biological Products
  - Plant Preparations: 622
    - Plant Extracts: 3916
      - PCM 4: 3
Pharmaceutical Preparations
- Plant Extracts: 3916
  - PCM 4: 3

Experts

1.	Cho, Min Kyung: 1 article (04/2003)
2.	Kim, Dong-Hyun: 1 article (04/2003)
3.	Kim, Sang Geon: 1 article (04/2003)
4.	Kwon, Jong Won: 1 article (04/2003)
5.	Lee, Myung Gull: 1 article (04/2003)
6.	Yim, Yoon Gyoon: 1 article (04/2003)

Related Diseases

1.	Neoplasms (Cancer) 09/01/1995 - "PCM-4, a substance well known in Europe and sold over-the-counter as a food supplement in the U.S., may soon receive Food and Drug Administration (FDA) permission to begin Phase-III clinical trials for use in HIV-positive and cancer patients. " 03/01/1983 - "The finding that PCM-4 has no direct growth-inhibition effect on tumor cells in vitro suggests that the antitumor activity of PCM-4 be elicited from the host-mediated response system." 03/01/1983 - "The antitumor activity of a water-soluble substance extracted from Chlorella regulararis S-50, PCM-4, against murine transplanted tumors was investigated. "
2.	Sarcoma 180 03/01/1983 - "PCM-4 also showed antitumor activity against Sarcoma 180 and Meth A by intraperitoneal administration. " 03/01/1983 - "By oral administration of PCM-4, both the growth of Sarcoma 180 and Meth A, subcutaneously implanted into mice, and ascites hepatoma AH 44 and AH 41C, intravenously implanted into rat, was inhibited. "
3.	Protein-Energy Malnutrition (Marasmus) 04/14/2003 - "The effects of cysteine on the pharmacokinetics of 2-(allylthio)pyrazine (2-AP) were investigated after intravenous administration of the drug (50 mg/kg) to control (Sprague-Dawley) rats (4-week fed on 23% casein diet), and rats with protein-calorie malnutrition (PCM, 4-week fed on 5% casein diet) and PCMC (PCM with 250 mg/kg of oral cysteine, twice daily starting from the fourth week). "
4.	Hepatocellular Carcinoma (Hepatoma) 03/01/1983 - "By oral administration of PCM-4, both the growth of Sarcoma 180 and Meth A, subcutaneously implanted into mice, and ascites hepatoma AH 44 and AH 41C, intravenously implanted into rat, was inhibited. "
5.	Ascites 03/01/1983 - "By oral administration of PCM-4, both the growth of Sarcoma 180 and Meth A, subcutaneously implanted into mice, and ascites hepatoma AH 44 and AH 41C, intravenously implanted into rat, was inhibited. "

Related Drugs and Biologics

1.	Cysteine (L-Cysteine)
2.	Caseins (Casein)
3.	2-(allylthio)pyrazine

Related Therapies and Procedures

1.	Intravenous Administration
2.	Oral Administration