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hemoglobin Hope

Gly replaced by Asp at position 136(H14) on beta chain

Also Known As:

Hb Hope

Networked: 17 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Hemoglobins: 37188
      - Abnormal Hemoglobins: 120
        hemoglobin Hope: 17
  - Hemeproteins: 194
    - Globins: 2716
      - Hemoglobins: 37188
        Abnormal Hemoglobins: 120
        hemoglobin Hope: 17

Experts

1.	Panyasai, Sitthichai: 3 articles (06/2016 - 07/2011)
2.	Pornprasert, Sakorn: 3 articles (06/2016 - 07/2011)
3.	Fucharoen, Goonnapa: 2 articles (06/2021 - 01/2004)
4.	Fucharoen, Supan: 2 articles (06/2021 - 01/2004)
5.	Chaibunruang, Attawut: 1 article (06/2021)
6.	Singha, Kritsada: 1 article (06/2021)
7.	Souvanlasy, Bounpalisone: 1 article (06/2021)
8.	Srivorakun, Hataichanok: 1 article (06/2021)
9.	Yamsri, Supawadee: 1 article (06/2021)
10.	Bartagi, Z: 1 article (05/2015)

Related Diseases

1.	Thalassemia 06/01/2021 - "Two δβ0 -thalassemia carriers (12.6 kb deletion) and three subjects with Hb Hope (β136GGT-GAT ) were identified. " 03/07/2012 - "However, using CE electrophoregram together with levels of HbA(0), HbA(2) and Hb Hope would be a more accurate and precise method for diagnosis of Hb Hope/β(0)-thalassemia." 03/07/2012 - "The elevation of HbA(2) in patients with heterozygous Hb Hope and with Hb Hope/α-thalassemia-1 SEA type deletion measured by CE leads to incorrect β-thalassemia trait diagnosis. " 03/07/2012 - "The highest levels of HbA(2) and Hb Hope were observed in samples with Hb Hope/β(0)-thalassemia. " 03/07/2012 - "Artifactually elevated HbA(2) levels (≥4%) were found in both groups of heterozygous Hb Hope and Hb Hope/α-thalassemia-1 SEA type deletion. "
2.	Anemia 01/01/1992 - "Association of Hb Hope [beta 136(H14)Gly----Asp] and alpha-thalassemia-2 (3.7 Kb deletion) causing severe microcytic anemia." 06/01/2016 - "We report the use of a capillary electrophoresis (CE) for diagnosis of co-inheritance of Hb Hope and Hb CS in 3 Thai females who had mild anemia with Hb and Hct varying from 91-114 g/L to 0.28-0.36 L/L, respectively. " 05/01/2015 - "Hemoglobin (Hb) Hope is a beta-globin chain variant with reduced oxygen (O₂) affinity, known to induce anemia. "
3.	Hemoglobinopathies 04/01/2010 - "All the detected hemoglobinopathies but one (an Hb Hope) had already been reported in the country. " 06/01/2016 - "Thus, the CE method provides an accurate diagnosis of Hb Hope and Hb CS which is useful in genetic counseling, prevention and control programs for these hemoglobinopathies. "
4.	beta-Thalassemia (Cooley's Anemia) 07/01/2011 - "Interference of hemoglobin Hope on beta-thalassemia diagnosis by the capillary electrophoresis Method."
5.	alpha-Thalassemia 01/01/2004 - "We report the hematological and molecular characterization of compound heterozygosity for hemoglobin (Hb) Hope/Hb E and double heterozygosity for Hb Hope/ alpha-thalassemia 2 found in 2 unrelated Thai individuals. " 01/01/2004 - "Molecular and hematological characterization of hemoglobin Hope/hemoglobin E and hemoglobin Hope/alpha-thalassemia 2 in Thai patients."

Related Drugs and Biologics

1.	Hemoglobins (Hemoglobin)
2.	Oxygen (Dioxygen)
3.	GAT
4.	beta-Globins (beta Globin)
5.	Sickle Hemoglobin
6.	Hemoglobin E
7.	Globins
8.	hemoglobin Lepore
9.	hemoglobin Camden
10.	Hemoglobin Constant Spring