|1.||Muro, Fumihito: 1 article (02/2015)|
|2.||Ohtoyo, Mamoru: 1 article (02/2015)|
|3.||Tamura, Masakazu: 1 article (02/2015)|
|4.||Hashimoto, Ryuji: 1 article (02/2015)|
|5.||Machinaga, Nobuo: 1 article (02/2015)|
|6.||Czuprynski, Charles: 1 article (01/2015)|
|7.||Bedale, Wendy: 1 article (01/2015)|
|8.||Wanless, Brandon J: 1 article (01/2015)|
|9.||Golden, Max C: 1 article (01/2015)|
|10.||Glass, Kathleen A: 1 article (01/2015)|
10/01/1989 - "Effect of oral and parenteral administration of B6 vitamers on the lymphopenia produced by feeding ammonia caramel or 2-acetyl-4(5)-(1,2,3,4-tetrahydroxy)butylimidazole to rats."
10/01/1988 - "A derivative of ammonia caramel colour (AC) is known to induce a selective lymphopenia in rats. "
01/01/1994 - "In the present study, female Balb/c mice fed a diet with a relatively high vitamin B6 content were exposed to 2 or 10% of a commercial Caramel Colour III preparation with a low THI content (less than 25 ppm) in the drinking water for 9 wk. Although this treatment did not induce a lymphopenia in the exposed mice, flow cytometric analysis of lymphocyte subpopulations demonstrated reductions in the CD4+ and CD8+ cell populations. "
02/01/2015 - "Caramel food colorant 2-acetyl-4-(tetrahydroxybutyl)imidazole (THI) causes lymphopenia in animals through sphingosine 1-phosphate lyase (SPL) inhibition. "
01/01/1996 - "2-acetyl-4(5)-(1,2,3,4-tetrahydroxybutyl)imidazole (THI) is an immunosuppressive component of caramel food colouring that causes lymphopenia in mice and rats by an unknown mechanism. "
|2.||Body Weight (Weight, Body)
05/01/1992 - "In the 13-wk subchronic toxicity study of Caramel Colour III, groups of 20 rats/sex were given concentrations of caramel colour equivalent to intakes of 0, 10, 15 or 20 g low-THI caramel colour/kg body weight/day or 20 g/kg of a high-THI caramel colour. "
05/01/1992 - "The colour fraction that was non-permeable to a 10,000-Da porosity membrane, contained 84% of the colour, 22% of the solids and 24% of the radioactivity of the [14C]Caramel Colour IV. The absorption, distribution and excretion of [14C]HMCF were evaluated in male rats after administration of single or multiple oral doses of the material at a dosage level of 2.5 g/kg body weight. "
05/01/1992 - "The concentrations of Caramel Colour IV in the drinking fluid were adjusted periodically to achieve the desired caramel colour intake per kg body weight. "
05/01/1992 - "Males given 15 or 20 g low-THI caramel colour/kg or 20 g high-THI caramel colour/kg and females given 20 g/kg of either type had lower body weights than controls. "
05/01/1992 - "The concentrations of caramel colour in the drinking fluid were adjusted periodically to achieve the desired caramel colour intake/kg body weight/day. "
08/12/1994 - "Studies reviewed in this paper demonstrated several other effects of Caramel Colour III on the immune system of rodents, including disturbed immune functions and changed resistance in infection models. "
04/01/1997 - "The usefulness of Lancefield group and the caramel smell for presumptive identification was examined, and the relation of the S milleri species, Lancefield group, and SDS-PAGE protein analysis to severity of infection and infection site was investigated. "
04/01/1997 - "To evaluate Lancefield grouping and caramel smell for presumptive identification of the Streptococcus milleri group, and to find whether Lancefield group, species, or protein profile correlated with virulence or infection site. "
|4.||Inflammatory Bowel Diseases (Inflammatory Bowel Disease)
05/26/2010 - "We report the antiinflammatory activity of the new DFA-enriched caramel in the trinitrobenzenesulfonic acid (TNBS) model of rat colitis, an experimental model that resembles human inflammatory bowel disease (IBD), and compare its effects with those obtained with a commercial sucrose caramel and with linear fructooligosaccharides (FOS). "
|1.||Vitamin B 6
|4.||Advanced Glycosylation End Products
|6.||Sweetening Agents (Sweeteners)