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CI 924

elevates HDL; structure & RN given in first source

Also Known As:

5,5'-((1,1-biphenyl)-2,5-diylbis(oxy))bis(2,2-dimethylpentanoic acid); CI-924

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Beach, Jeremy: 1 article (11/2022)
2.	Cherry, Nicola: 1 article (11/2022)
3.	Galarneau, Jean-Michel: 1 article (11/2022)
4.	Chan, Isaac H Y: 1 article (01/2017)
5.	Dobler, Claudia C: 1 article (01/2017)
6.	Kaushik, Nishta: 1 article (01/2017)

Related Diseases

1.	Neoplasms (Cancer) 05/01/1996 - "The hepatic tumorigenicity of CI-924 (5,5'-(1,1'-biphenyl)-2,5-diylbis(oxy)(2,2-dimethylpentanoic acid)), a hypolipidemic agent, was evaluated in 50 B6C3F1 mice/sex/dose given drug in the diet at 0, 5, 25, and 75 mg/kg/day for 2 yr. Peroxisomal and drugmetabolizing enzyme determinations, as well as ultrastructural evaluations, were conducted in subsets of these same groups, because drugs of this class cause peroxisome proliferation and hepatic tumors in rodents. " 05/01/1996 - "Total cytochrome P-450 was increased in both sexes given 75 mg/kg. There were dose-dependent decreases in glutathione S-transferase in males and increased glutathione peroxidase in both sexes at 25 and 75 mg/kg. In conclusion, this study demonstrated that while CI-924 induced hepatic tumors in male and female B6C3F1 mice the associated peroxisome proliferation, while moderate in females, was only weak in the males after 2 yr of exposure."
2.	Liver Cell Adenoma (Hepatocellular Adenoma) 05/01/1996 - "CI-924 elicited dose-dependent increases in the incidence of hepatocellular adenomas and carcinomas in both sexes that were statistically significant at 75 mg/kg. Stereologic evaluation revealed significant increases in hepatocellular peroxisome volume ratio, due to increased numbers of peroxisomes, in females at all doses and males at 75 mg/kg. Peroxisomal enzyme activity measurements revealed no change in catalase, but dose-dependent increases in carnitine acetyltransferase and cyanide-insensitive beta-oxidation in both sexes. "
3.	Tuberculosis (Tuberculoses) 01/01/2017 - "The pooled tuberculosis incidence from 15 cohorts was 1249 per 100 000 person-years of follow-up (95% CI 924-1574; I2=98%). "
4.	Carcinoma (Carcinomatosis) 05/01/1996 - "CI-924 elicited dose-dependent increases in the incidence of hepatocellular adenomas and carcinomas in both sexes that were statistically significant at 75 mg/kg. Stereologic evaluation revealed significant increases in hepatocellular peroxisome volume ratio, due to increased numbers of peroxisomes, in females at all doses and males at 75 mg/kg. Peroxisomal enzyme activity measurements revealed no change in catalase, but dose-dependent increases in carnitine acetyltransferase and cyanide-insensitive beta-oxidation in both sexes. "
5.	Birth Weight (Birth Weights) 11/15/2022 - "Birth weight was lower in those reporting whole-body vibration (β = -596 g, 95% CI -924 to -267) and increased with the welder's body mass index (β = 36 g, 95% CI 12-61). "

Related Drugs and Biologics

1.	Glutathione Transferase (Glutathione S-Transferase)
2.	Glutathione Peroxidase
3.	Cytochrome P-450 Enzyme System (Cytochrome P450)
4.	Enzymes
5.	Cyanides (Isocyanides)
6.	Catalase
7.	Carnitine O-Acetyltransferase
8.	Hypolipidemic Agents (Antihyperlipidemics)