N-benzyloxycarbonylprolylprolinal

inhibitor of prolyl endopeptidase

Also Known As:

N-benzyloxycarbonyl-prolyl-prolinal; N-benzyloxycarbonyl-prolylprolinal; Z-Pro-Prolinal; 1-Pyrrolidinecarboxylic acid, 2-((2-formyl-1-pyrrolidinyl)carbonyl)-, 1,1-dimethylethyl ester, (S-(R*,R*))-

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Oligopeptides: 519
    - Dipeptides: 945
      - N-benzyloxycarbonylprolylprolinal: 4

Experts

1.	Bai, Ruoli: 1 article (01/2009)
2.	Bonate, Peter L: 1 article (01/2009)
3.	Copeland, Terry D: 1 article (01/2009)
4.	Edler, Michael C: 1 article (01/2009)
5.	Hamel, Ernest: 1 article (01/2009)
6.	Ludueña, Richard F: 1 article (01/2009)
7.	Pettit, George R: 1 article (01/2009)
8.	Lehtonen, Sárka: 1 article (12/2006)
9.	Männistö, Pekka T: 1 article (12/2006)
10.	Puttonen, Katja A: 1 article (12/2006)

Related Diseases

1.	Neuroblastoma 12/01/2006 - "We studied the ability of prolyl oligopeptidase (POP) inhibitors, Z-Pro-Prolinal and JTP-4819, to prevent translocation of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and formation of reactive oxygen species (ROS), in 6-hydroxydopamine (6-OHDA) and cytosine arabinoside (Ara-C) treated monkey fibroblast (CV1-P) and human neuroblastoma (SH-SY5Y) cells. "
2.	Leukemia 01/01/2009 - "When CCRF-CEM human leukemia cells were treated with N-benzyloxycarbonylprolylprolinal (BCPP), an inhibitor of prolyl oligopeptidase, there was a 30-fold increase in the IC(50) of tasidotin and a marked increase in intracellular [(3)H]tasidotin. "
3.	Ischemia 05/14/1999 - "Z-Pro-Prolinal, vasopressin-(4-9) and TRH protected pyramidal cells in the CA1 subfield of the rat hippocampus from delayed neuronal death after 10-min ischemia. " 05/14/1999 - "We investigated the effects of the prolyl endopeptidase inhibitors 1-[1-(Benzyloxycarbonyl)-L-prolyl]prolinal (Z-Pro-Prolinal) and N-benzyloxycarbonyl-thioprolyl-thioprolinal-dimethylaceta l (ZTTA) on delayed neuronal death induced by four-vessel-occlusion transient ischemia in rats. "
4.	Amnesia (Dissociative Amnesia) 12/01/1987 - "In the passive avoidance learning test using rats, pretreatment with Z-Pro-prolinal prevented the induction of amnesia by scopolamine at the dose of 1 mumol/animal, i.p. "

Related Drugs and Biologics

1.	Prolyl Oligopeptidases
2.	Reactive Oxygen Species (Oxygen Radicals)
3.	Oxidopamine (6 Hydroxydopamine)
4.	Scopolamine (Hyoscine)
5.	Glyceraldehyde-3-Phosphate Dehydrogenases (GAPD)
6.	Cytarabine (Cytosar-U)
7.	tasidotin
8.	N- benzyloxycarbonyl- thioprolyl- thioprolinal- dimethylacetal
9.	JTP 4819
10.	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))