HOME PRODUCTS COMPANY CONTACT FAQ

Research Dictionary Pharma

Sign Up FREE or Login

holocyclotoxin

from salivary glands of Australian parasitic tick Ixodes holocyclus

Also Known As:

Holocyclotoxin

Networked: 8 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Complex Mixtures: 1906
- Venoms: 4328
  - Arthropod Venoms: 770
    - holocyclotoxin: 8
Biological Factors: 2472
- Biological Toxins: 20
  - Venoms: 4328
    - Arthropod Venoms: 770
      - holocyclotoxin: 8

Experts

1.	Tabor, Ala E: 2 articles (09/2021 - 01/2018)
2.	Ijaz, Hina: 2 articles (01/2018 - 01/2016)
3.	Koehbach, Johannes: 2 articles (01/2018 - 01/2016)
4.	Rodriguez-Valle, Manuel: 2 articles (01/2018 - 01/2016)
5.	Roeber, Florian: 1 article (01/2021)
6.	Webster, Maurice: 1 article (01/2021)
7.	Agnew, Kim: 1 article (01/2018)
8.	Barrero, Roberto A: 1 article (01/2018)
9.	Bellgard, Matthew I: 1 article (01/2018)
10.	Booth, Mitchell: 1 article (01/2018)

Related Diseases

1.	Tick Paralysis (Paralysis, Tick) 01/01/2023 - "These cats were immunized against paralysis tick holocyclotoxin prior to the study commencing. " 03/01/1983 - "Three beagle dogs were immunised against the paralysing effects of holocyclotoxin, using toxic extracts derived from salivary glands of the Australian paralysis tick, Ixodes holocyclus. " 09/16/2021 - "The Australian paralysis tick Ixodes holocyclus has perplexed research veterinarians since the 1920s; however, not until the 2000s did biotechnology exist to elucidate the neurotoxin-holocyclotoxin family of toxins leading to a proof of concept vaccine cocktail. " 04/01/1986 - "Toxoid stimulation in dogs of high titres of neutralising antibodies against holocyclotoxin, the paralysing toxin of the Australian paralysis tick Ixodes holocyclus."
2.	Paralysis (Palsy) 01/01/2018 - "The database contributed to the identification and subsequent characterization of the holocyclotoxin family that will inform the development of novel anti-paralysis control methods." 01/01/2021 - "This three-host tick produces a potent neurotoxin (holocyclotoxin) that induces a rapidly ascending flaccid paralysis that can be fatal to companion animals and larger mammals such as cattle and horses. " 01/01/2016 - "Here, we report that three members of the holocyclotoxin family; HT-1 (GenBank AY766147), HT-3 (GenBank KP096303) and HT-12 (GenBank KP963967) induce muscle paralysis by inhibiting the dependence of transmitter release on extracellular calcium. "
3.	Anisocoria 10/01/2023 - "It is proposed that anisocoria in cases of TP with a tick located remote from the head and neck is due to an intrinsic latent asymmetry in the safety factor for pupillary efferent function that is unmasked by a systemically distributed holocyclotoxin inhibiting neural transmission within this system, and this is the prevailing pathomechanism, rather than a direct local effect, underscoring anisocoria with a tick located on the head or neck."

Related Drugs and Biologics

1.	Neurotoxins
2.	Vaccines
3.	Toxoids
4.	Calcium
5.	Antibodies