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ethylenediamine platinum(II) malonate (JM 40)

Also Known As:

JM 40; JM-40; NSC 146068; NSC-146,068; malopen; Platinum, (1,2-ethanediamine-N,N')(propanedioato(2-)-O,O')-, (SP-4-2)-

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organoplatinum Compounds
    - ethylenediamine platinum(II) malonate: 3

Related Diseases

1.	Neoplasms (Cancer) 01/01/1985 - "Cisplatin and carboplatin caused some growth delay of Pe, while JM-40, spiroplatin, and iproplatin failed to affect tumor growth. " 12/01/1989 - "A randomized double-blind study was conducted to compare the anti-emetic efficacy of 1 mg/kg vs 2 mg/kg metoclopramide, administered 5 times over a period of 8.5 h in 50 cancer patients treated with platinum-containing regimens (cisplatin, ethylenediamine platinum II malonate or spiroplatin). " 01/01/1985 - "Platinum concentrations in the two tumors at 24 hr were similar for cisplatin and carboplatin, but differed for iproplatin, spiroplatin, and JM-40. "
2.	Vomiting 08/01/1987 - "Vomiting in order of severity occurred after TNO-6, CHIP, CDDP and JM-40, while CBDCA did not cause any vomiting. " 12/01/1989 - "However, in the group of patients who received a high dosage of cisplatin (70-100 mg/m2), or ethylenediamine platinum II malonate (800-900 mg/m2), there was a significant difference in nausea and vomiting between patients who had and those who had not received prior chemotherapy, most probably due to anticipation. "
3.	Proteinuria 08/01/1987 - "JM-40 did not cause significant proteinuria. "
4.	Nausea 12/01/1989 - "However, in the group of patients who received a high dosage of cisplatin (70-100 mg/m2), or ethylenediamine platinum II malonate (800-900 mg/m2), there was a significant difference in nausea and vomiting between patients who had and those who had not received prior chemotherapy, most probably due to anticipation. "

Related Drugs and Biologics

1.	spiroplatin
2.	Platinum
3.	Cisplatin (Platino)
4.	Metoclopramide (Reglan)
5.	Antiemetics
6.	Carboplatin (JM8)
7.	iproplatin (JM9)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)