|1.||Vlodavsky, Israel: 142 articles (01/2016 - 01/2002)|
|2.||Ilan, Neta: 77 articles (09/2015 - 05/2002)|
|3.||Zcharia, Eyal: 34 articles (06/2014 - 04/2002)|
|4.||Vlodavsky, I: 27 articles (08/2015 - 06/2000)|
|5.||Sanderson, Ralph D: 25 articles (01/2015 - 12/2003)|
|6.||Elkin, Michael: 22 articles (12/2014 - 04/2002)|
|7.||Marchetti, Dario: 21 articles (05/2015 - 07/2002)|
|8.||Li, Jin-Ping: 20 articles (01/2015 - 05/2005)|
|9.||Nakajima, Motowo: 20 articles (10/2012 - 11/2002)|
|10.||Nadir, Yona: 19 articles (12/2015 - 10/2005)|
06/22/2007 - "Our results suggest that genetic downregulation of the expression of heparanase may serve as an efficient cancer therapeutic for human HCC."
03/09/2012 - "Although heparanase (HPA) is a potential target for patients with advanced tumor diseases, the efficacy of immunotherapeutic strategies targeting HPA has never been evaluated. "
08/01/2015 - "Evaluation of the Antitumor Efficacy of RNAi-Mediated Inhibition of CDC20 and Heparanase in an Orthotopic Liver Tumor Model."
12/22/2015 - "The present study was aimed to evaluate heparanase procoagulant activity in myeloproliferative neoplasms. "
01/01/2015 - "The study shows that salivary heparanase levels, as detected by the ELISAs, can be used to diagnose and provide an accurate prognosis for malignant salivary gland tumors. "
|2.||Neoplasm Metastasis (Metastasis)
01/01/2008 - "This study is to learn the correlation between lymph-node metastasis and the combined expression of Heparanase (Hpa) and C-erbB-2. "
04/01/2015 - "Biochemical analysis indicated that the invertebrate glycan also inhibits heparanase, a key player in cell invasion and metastasis. "
09/02/2014 - "Heparanase is implicated in cell invasion, tumour metastasis and angiogenesis. "
01/01/2014 - "Heparanase is an endoglycosidase enzyme present in activated leucocytes, mast cells, placental tissue, neutrophils and macrophages, and is involved in tumour metastasis and tissue invasion. "
01/18/2012 - "Previous work has demonstrated that heparanase plays important roles in various biological processes including angiogenesis, wound healing and metastasis. "
|3.||Breast Neoplasms (Breast Cancer)
01/01/2014 - "The aim of this study is to determine the differential regulation of heparanase gene expression in specific stages of breast cancer by DNA methylation. "
07/15/2007 - "The present study was undertaken to elucidate molecular mechanisms responsible for heparanase overexpression in breast cancer. "
06/01/2007 - "PBMC samples from all breast cancer patients at study entry showed the expression of heparanase, whereas no expression was observed for healthy women. "
04/01/2006 - "The present study was undertaken to investigate the role of heparanase in local growth and angiogenesis of primary breast tumors. "
11/01/2004 - "This study was to investigate correlation of heparanase expression to angiogenesis and prognosis of breast cancer. "
|4.||Stomach Neoplasms (Stomach Cancer)
04/01/2010 - "Given that previous studies indicated that early growth response 1 (EGR1) exerts pro-tumorigenic effects through regulating heparanase (HPA) transcription, it was hypothesized that EGR1 may correlate with the progression of gastric cancer. "
01/01/2010 - "The aim of this study is to determine whether silencing of heparanase expression can abolish the malignant characteristics of gastric cancer cells. "
01/01/2010 - "Our studies indicated that heparanase was frequently expressed in advanced gastric cancers. "
01/01/2014 - "These data suggest that heparanase facilitates invasion and migration of human gastric cancer cells probably through elevating phosphorylation of Src and p38. "
01/01/2014 - "We first evaluated the endogenous expression of heparanase in human gastric cancer cell lines and found Heparanase expression higher in SGC-7901 than MGC-803. "
04/01/2013 - "In the present study we evaluated the role of heparanase promoter methylation in colon carcinoma. "
10/01/2012 - "The aim of this study was to investigate the expression patterns of heparanase and COX-2 during progression of oral epithelial dysplasia (OED) to carcinoma. "
02/01/2015 - "Heparanase 1 is more intensely expressed in the glandular tissue of high-grade compared with type I carcinomas. "
12/07/2014 - "Pv11 was mapped to intron 9 of the heparanase 2 gene (HPSE2) locus, a very large gene encoding heparanase 2, which in humans is associated with multiple carcinomas. "
12/01/2014 - "Macrophage polarization in pancreatic carcinoma: role of heparanase enzyme."
|2.||Heparitin Sulfate (Heparan Sulfate)
|4.||Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)
|6.||Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
|7.||Syndecan-1 (Syndecan 1)
|8.||Small Interfering RNA (siRNA)
|9.||Conditioned Culture Media
|1.||Heterologous Transplantation (Xenotransplantation)
|2.||Homologous Transplantation (Allograft)