1-oleoyl-2-acetylglycerol

Also Known As:

1-O-octadecenoyl-2-O-acetylglycerol; 1-oleoyl-2-acetyl-glycerol; 1-oleoyl-2-acetyl-sn-glycerol; 1-oleyl-2-acetylglycerol; oleoylacetylglycerol; oleyl acetyl glycerol; 9-Octadecenoic acid (Z)-, 2-(acetyloxy)-3-hydroxypropyl ester, (S)-

Networked: 37 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Lipids: 114793
- Glycerides: 109
  - Diglycerides: 1037
    - 1-oleoyl-2-acetylglycerol: 37

Experts

1.	Lin, Mo-Jun: 2 articles (01/2016 - 02/2010)
2.	Liu, Dao Yan: 2 articles (10/2007 - 04/2007)
3.	Scholze, Alexandra: 2 articles (10/2007 - 04/2007)
4.	Tepel, Martin: 2 articles (10/2007 - 04/2007)
5.	Zhu, Zhi Ming: 2 articles (10/2007 - 04/2007)
6.	Zidek, Walter: 2 articles (10/2007 - 04/2007)
7.	Bai, Li-Ping: 1 article (04/2022)
8.	Chen, Ya-Li: 1 article (04/2022)
9.	Zheng, Ai: 1 article (04/2022)
10.	Aherrahrou, Redouane: 1 article (01/2021)

Related Diseases

1.	Neoplasms (Cancer) 07/01/1990 - "Divergent effects of 1-oleoyl-2-acetylglycerol and tumor-promoting phorbol ester on rat granulosa cell steroidogenesis in vitro." 07/01/1986 - "Other protein kinase C-activating substances such as 12-O-tetradecanoylphorbol-13-acetate and 1-oleoyl-2-acetyl-glycerol could substitute for PDBU, but 4 alpha-phorbol-12,13-didecanoate, which is inactive for both tumor promotion and protein kinase C activation, was ineffective in this capacity. " 08/01/1988 - "This study shows that the membrane-permeable stereospecific 1-oleoyl-2-acetyl-sn-glycerol (OAG), which is the analog of the natural 1,2-diacylglycerol (DAG), can stimulate the growth of ascites tumor cells. " 07/01/1993 - "In ascites tumor cells, phosphoinositide metabolism can be activated by short-term treatment with exogenously added 1-oleoyl-2-acetyl-sn-glycerol (OAG), which is the membrane-permeable analog of diacylglycerides (DAG). " 05/01/1989 - "Effect of 1-oleoyl-2-acetyl-sn-glycerol on inositol lipid metabolism of ascites tumor cells in culture."
2.	Ascites 08/01/1988 - "This study shows that the membrane-permeable stereospecific 1-oleoyl-2-acetyl-sn-glycerol (OAG), which is the analog of the natural 1,2-diacylglycerol (DAG), can stimulate the growth of ascites tumor cells. " 07/01/1993 - "In ascites tumor cells, phosphoinositide metabolism can be activated by short-term treatment with exogenously added 1-oleoyl-2-acetyl-sn-glycerol (OAG), which is the membrane-permeable analog of diacylglycerides (DAG). " 05/01/1989 - "Effect of 1-oleoyl-2-acetyl-sn-glycerol on inositol lipid metabolism of ascites tumor cells in culture." 01/01/1988 - "Guanine nucleotides activate cytosolic phospholipase C of ascites tumour cells stimulated by 1-oleoyl-2-acetyl-sn-glycerol." 05/01/1989 - "1-Oleoyl-2-acetyl-sn-glycerol (OAG), the membrane-permeable analogue of 1,2-diacylglycerol (DAG), which stimulates ascites tumor cell proliferation, was used to study its effect on phosphoinositide metabolism. "
3.	Hypoxia (Hypoxemia) 08/01/2011 - "One hour of hypoxia followed by reoxygenation significantly reduced the vasorelaxation (70.3 ± 6.4 vs. 88.9 ± 3.5%) and NO concentration (24.0 ± 1.3 vs. 45.2 ± 2.8 nmol/L), and they were restored by pre-incubation with the TRPC3/6/7 activator 1-oleoyl-2-acetyl-sn-glycerol (96.4 ± 1.8% and 41.1 ± 4.7 nmol/L, respectively). " 01/01/2016 - "The present study quantified caveolae number and Cav-1 expression, and determined the effects of caveolae disruption on ET-1, cyclopiazonic acid (CPA) and 1-Oleoyl-2-acetyl-glycerol (OAG)-induced contraction in PAs and Ca(2+) influx in PASMCs of chronic hypoxia (CH)- and monocrotaline (MCT)-induced PH rats. "
4.	Uterine Cervical Neoplasms (Cancer of the Cervix) 04/07/2022 - "This study aimed to observe the effect of transient receptor potential canonical channel 6 (TRPC6) antagonist 1-(β-[3-(4-method-phenyl) propoxy]-4-methoxyphenethyl)-1H-imidazole hydrate (SKF-96365) and its agonist 1-oleoyl-2-acetyl-sn-glycerol (OAG) on the proliferation of cervical cancer cell lines HeLa and SiHa, deoxyribonucleic acid (DNA) synthesis, cell migration, and TRPC6 expression. "
5.	Melanoma (Melanoma, Malignant) 07/01/2016 - "In order to identify the cellular factors involved in human melanogenesis, we carried out shRNA-mediated loss-of-function screening in conjunction with induction of melanogenesis by 1-oleoyl-2-acetyl-glycerol (OAG) in human melanoma cells using biochemical and visual assays. " 09/01/1994 - "The melanogenic responses to 1-oleoyl-2-acetylglycerol and ultraviolet radiation were unaffected by inhibition of protein kinase C with Ro31-8220, or ablation by downregulation with 500 nM TPA, in human melanocytes and melanoma cells. " 11/01/1992 - "Their expression is enhanced upon treatment by the diacylglycerol analogue 1-oleoyl-2-acetylglycerol, which can induce melanin synthesis in amelanotic human melanoma cells in a dose-dependent manner. "

Related Drugs and Biologics

1.	1,2-diacylglycerol
2.	Phosphatidylinositols (Phosphatidylinositol)
3.	DNA (Deoxyribonucleic Acid)
4.	TRPC6 Cation Channel
5.	Monocrotaline
6.	imidazole
7.	cyclopiazonic acid
8.	Phorbol Esters
9.	Diglycerides
10.	Protein Kinase C