|1.||Klingenspor, Martin: 3 articles (10/2014 - 01/2011)|
|2.||Flachs, P: 3 articles (08/2014 - 12/2004)|
|3.||Scarpace, P J: 3 articles (02/2013 - 01/2002)|
|4.||Scarpace, Philip J: 3 articles (04/2011 - 08/2002)|
|5.||Zhang, Yi: 3 articles (04/2011 - 08/2002)|
|6.||Saito, M: 3 articles (10/2008 - 11/2001)|
|7.||Kieffer, Timothy J: 2 articles (11/2015 - 12/2012)|
|8.||Fromme, Tobias: 2 articles (10/2014 - 01/2011)|
|9.||Bardova, K: 2 articles (08/2014 - 12/2004)|
|10.||Kopecký, J: 2 articles (08/2014 - 01/2013)|
05/01/2013 - "These brite (brown in white) adipocytes share characteristics with classical brown adipocytes including a multilocular appearance and the expression of the thermogenic protein uncoupling protein 1. In this study, we compared two inbred mouse strains 129S6sv/ev and C57BL6/N known for their different propensity to diet-induced obesity. "
12/01/1997 - "Studies of genetic variability of the uncoupling protein 1 gene in Caucasian subjects with juvenile-onset obesity."
05/01/1996 - "C57BL6/J mice with the expression of the mitochondrial uncoupling protein (UCP) gene from the fat-specific aP2 gene promoter were used to study the mechanism by which the aP2-Ucp transgene affects adiposity and reduces high-fat diet induced obesity. "
07/01/2015 - "Effect of Zingiber officinale Supplementation on Obesity Management with Respect to the Uncoupling Protein 1 -3826A>G and ß3-adrenergic Receptor Trp64Arg Polymorphism."
05/01/2015 - "Brown and beige adipose tissue may represent important therapeutic targets for the treatment of diabetes and obesity as these organs dissipate nutrient energy as heat through the thermogenic uncoupling protein 1 (UCP1). "
|2.||Body Weight (Weight, Body)
01/01/2015 - "Furthermore, this is accompanied by downregulation of uncoupling protein 1 expression and PPARγ coactivator-1 alpha in BAT and a rapid body weight gain. "
09/01/1983 - "When the thermogenin content of the animal was expressed per gram body weight, the content was more than doubled (from 22 to 47 pmol/g body weight) in the high EFA group, but was unaltered in the low EFA group. "
02/01/2007 - "Food intake, body weight, adiposity, and uncoupling protein 1 expression increased with antagonist infusion in controls but elevated only marginally in leptin-resistant rats. "
09/01/2005 - "Further, circulating levels of leptin were positively correlated with body weight and body fat mass, and negatively correlated with energy intake and uncoupling protein 1 contents. "
11/01/2003 - "However, MCH blockade led to a significant drop in body weight, which was accompanied by decreased liver glycogen, increased relative body fat, increased absolute and relative interscapular brown adipose tissue mass, increased uncoupling protein 1 expression in brown adipose tissue, and increased consumption of lean body mass. "
01/27/2006 - "Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes."
02/19/2008 - "Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1."
06/01/2002 - "To determine whether respiratory uncoupling can prevent insulin resistance-related hypertension, we crossed transgenic mice expressing uncoupling protein 1 (UCP1) in skeletal muscle with lethal yellow (A(y)/a) mice, genetically obese animals known to have elevated blood pressure. "
01/01/2005 - "Furthermore, brown adipocytes are also target cells for rosiglitazone action since they show a high expression of peroxisome proliferator activated receptor gamma, and rosiglitazone increased the expression of the thermogenic uncoupling protein 1. Rosiglitazone ameliorates insulin resistance provoked by TNF-alpha, completely restoring insulin-stimulated glucose uptake in parallel to the insulin signalling cascade. "
05/01/2004 - "This study analyzes the relationship between risk factors related to overweight/obesity, insulin resistance, lipid tolerance, hypertension, endothelial function and genetic polymorphisms associated with: i) appetite regulation (leptin, melanocortin-3-receptor (MCR-3), dopamine receptor 2 (D2R)); ii) adipocyte differentiation and insulin sensitivity (peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2), tumor necrosis factor-alpha (TNF-alpha)); iii) thermogenesis and free fatty acid (FFA) transport/catabolism (uncoupling protein-1 (UCP1), lipoprotein lipase (LPL), beta2- and beta3-adrenergic receptor (beta2AR, beta3AR), fatty acid transport protein-1 (FATP-1) and iv) lipoproteins (apoliprotein E (apoE), apo CIII). "
07/01/1985 - "Mitochondrial thermogenin content is unchanged during atrophy of BAT of fasting mice."
11/01/1986 - "The effects of unilateral surgical denervation on brown adipose tissue (BAT) composition were evaluated to assess the importance of the sympathetic innervation in the maintenance of a high concentration of the uncoupling protein thermogenin in cold-acclimated (CA) mice and to assess whether suppression of neural activity could account for BAT atrophy observed during fasting or when CA mice are returned to a thermoneutral environment (33 degrees C). "
07/01/1986 - "Fasting-induced atrophy was characterized by reductions in tissue mass, DNA, protein, and thermogenin. "
11/01/1986 - "Denervation-induced BAT atrophy was characterized by protein and thermogenin losses in absence of changes in the tissue cellularity (DNA content). "
08/01/1990 - "In euthyroid mice, a 48-h fast caused brown fat (BAT) atrophy characterized by loss of tissue proteins, succinate dehydrogenase (SDH), and a significant reduction in mitochondrial uncoupling protein (UCP) content. "
12/01/2008 - "Although physical activity is the dominant mechanism for dissipating excess energy, a system of thermogenesis that evolved to protect the body from hypothermia is based upon the uncoupling of oxidative phosphorylation in brown adipocytes by the mitochondrial uncoupling protein (UCP1). "
06/01/2013 - "Brown adipose tissue (BAT) plays a key role in energy homeostasis and thermogenesis in animals, conferring protection against diet-induced obesity and hypothermia through the action of uncoupling protein 1 (UCP1). "
10/01/2013 - "In contrast to white adipocytes, which store energy, brown adipocytes generate heat via mitochondrial uncoupling protein 1, thereby acting as a defence against hypothermia and, potentially, obesity. "
07/20/2012 - "Brown fat generates heat via the mitochondrial uncoupling protein UCP1, defending against hypothermia and obesity. "
|3.||Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
|4.||Proteins (Proteins, Gene)
|6.||Succinate Dehydrogenase (Fumarate Reductase)
|8.||Adrenergic Receptors (Adrenergic Receptor)
|9.||Lipoprotein Lipase (Diacylglycerol Lipase)
|10.||mitochondrial uncoupling protein (thermogenin)
|2.||Highly Active Antiretroviral Therapy (HAART)
|3.||Drug Therapy (Chemotherapy)