mitochondrial uncoupling protein (thermogenin)

32,000 dalton uncoupling protein in mitochondrial cristae of brown adipocytes; amino acid sequence known; GenBank AJ223983 (Arabidopsis), Y11220 and AJ002586 ( Solanum tuberosum)
Also Known As:
thermogenin; uncoupling protein 1; BAT uncoupling protein; PUMP protein, Arabidopsis; UCP1 protein, human; Ucp1 protein, mouse; Ucp1 protein, rat; brown adipose tissue uncoupling protein; uncoupling mitochondrial protein, Arabidopsis; uncoupling protein 1 (mitochondrial, proton carrier), human; uncoupling protein 1, mitochondrial, mouse; uncoupling protein 1, rat; uncoupling protein 1a; uncoupling protein, mitochondrial membrane
Networked: 151 relevant articles (6 outcomes, 18 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Klingenspor, Martin: 3 articles (10/2014 - 01/2011)
2. Flachs, P: 3 articles (08/2014 - 12/2004)
3. Scarpace, P J: 3 articles (02/2013 - 01/2002)
4. Scarpace, Philip J: 3 articles (04/2011 - 08/2002)
5. Zhang, Yi: 3 articles (04/2011 - 08/2002)
6. Saito, M: 3 articles (10/2008 - 11/2001)
7. Kieffer, Timothy J: 2 articles (11/2015 - 12/2012)
8. Fromme, Tobias: 2 articles (10/2014 - 01/2011)
9. Bardova, K: 2 articles (08/2014 - 12/2004)
10. Kopecký, J: 2 articles (08/2014 - 01/2013)

Related Diseases

1. Obesity
2. Body Weight (Weight, Body)
3. Insulin Resistance
01/27/2006 - "Association of the -112A>C polymorphism of the uncoupling protein 1 gene with insulin resistance in Japanese individuals with type 2 diabetes."
02/19/2008 - "Dissociation of obesity and insulin resistance in transgenic mice with skeletal muscle expression of uncoupling protein 1."
06/01/2002 - "To determine whether respiratory uncoupling can prevent insulin resistance-related hypertension, we crossed transgenic mice expressing uncoupling protein 1 (UCP1) in skeletal muscle with lethal yellow (A(y)/a) mice, genetically obese animals known to have elevated blood pressure. "
01/01/2005 - "Furthermore, brown adipocytes are also target cells for rosiglitazone action since they show a high expression of peroxisome proliferator activated receptor gamma, and rosiglitazone increased the expression of the thermogenic uncoupling protein 1. Rosiglitazone ameliorates insulin resistance provoked by TNF-alpha, completely restoring insulin-stimulated glucose uptake in parallel to the insulin signalling cascade. "
05/01/2004 - "This study analyzes the relationship between risk factors related to overweight/obesity, insulin resistance, lipid tolerance, hypertension, endothelial function and genetic polymorphisms associated with: i) appetite regulation (leptin, melanocortin-3-receptor (MCR-3), dopamine receptor 2 (D2R)); ii) adipocyte differentiation and insulin sensitivity (peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2), tumor necrosis factor-alpha (TNF-alpha)); iii) thermogenesis and free fatty acid (FFA) transport/catabolism (uncoupling protein-1 (UCP1), lipoprotein lipase (LPL), beta2- and beta3-adrenergic receptor (beta2AR, beta3AR), fatty acid transport protein-1 (FATP-1) and iv) lipoproteins (apoliprotein E (apoE), apo CIII). "
4. Atrophy
5. Hypothermia

Related Drugs and Biologics

1. Insulin (Novolin)
2. Glucose (Dextrose)
3. Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4. Proteins (Proteins, Gene)
5. PPAR gamma
6. Succinate Dehydrogenase (Fumarate Reductase)
7. rosiglitazone (Avandia)
8. Adrenergic Receptors (Adrenergic Receptor)
9. Lipoprotein Lipase (Diacylglycerol Lipase)
10. mitochondrial uncoupling protein (thermogenin)

Related Therapies and Procedures

1. Denervation
2. Highly Active Antiretroviral Therapy (HAART)
3. Drug Therapy (Chemotherapy)