cucurbitacin D

01/01/2013 - "Recently, it was reported that Cucurbitacin D (CuD) isolated from Trichosanthes kirilowii also induces apoptosis in several cancer cells. "
04/01/2009 - "These results suggest that cucurbitacin D isolated from Trichosanthes kirilowii could be a valuable candidate for anti-tumor drug."
12/31/2019 - "Natural products have been widely investigated as potential candidates in cancer therapies, and cucurbitacin D (Cuc D) has shown excellent anticancer properties in various models. "
11/08/2016 - "Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer."
12/01/2013 - "We previously reported that cucurbitacin D isolated from Trichosanthes kirilowii has anti-tumor roles to leukemia cells. "

11/08/2016 - "These results demonstrate the potential therapeutic efficacy of Cucurbitacin D against cervical cancer."
11/08/2016 - "Cucurbitacin D inhibited viability and growth of cervical cancer cells (CaSki and SiHa) in a dose-dependent manner. "
11/08/2016 - "Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer."
11/08/2016 - "Cucurbitacin D treatment (1 mg/kg body weight) effectively inhibited growth of cervical cancer cells derived orthotopic xenograft tumors in athymic nude mice. "
11/08/2016 - "In this study, we for the first time, investigated the potential anti-cancer effects of a novel analogue of cucurbitacin (Cucurbitacin D) against cervical cancer in vitro and in vivo. "

06/15/2011 - "In this study, cucurbitacin D was found to inhibit proliferation and to induce apoptosis of T-cell leukemia cells. "
04/01/2016 - "Autophagy is associated with cucurbitacin D-induced apoptosis in human T cell leukemia cells."
06/15/2011 - "Cucurbitacin D induced apoptosis through suppression of proteasome activity both in vitro and in vivo, making cucurbitacin D a promising candidate for clinical applications in the treatment of T-cell leukemia."
06/15/2011 - "The effects of cucurbitacin D on the proliferation and apoptotic induction of T-cell leukemia cells using the Cell viability assay and Annexin V staining were evaluated. "
06/15/2011 - "Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T-cell leukemia."

02/01/2013 - "The purpose of this study was to elucidate the effects of cucurbitacin D on human endometrial and ovarian cancer cells. "
02/01/2013 - "Our results suggest that cucurbitacin D might be a new therapeutic option for the treatment of endometrial and ovarian cancers."
02/01/2013 - "All endometrial and ovarian cancer cell lines were sensitive to the growth-inhibitory effect of cucurbitacin D. "
02/01/2013 - "Human endometrial and ovarian cancer cells were treated with various concentrations of cucurbitacin D, and its effects on cell growth, the cell cycle, apoptosis, and their related measurements were investigated in vitro. "
02/01/2013 - "Cucurbitacin D induces growth inhibition, cell cycle arrest, and apoptosis in human endometrial and ovarian cancer cells."

09/01/2014 - "For this purpose, we treated the non-small cell lung cancer cell line NSCLC-N6 with the natural product cucurbitacin D (CucD) - extracted from the plant Ecballium elaterium in order first to assess its in vitro cytotoxicity, but also to study the genetic changes that it could bring out. "
09/01/2014 - "Cucurbitacin-D-induced CDK1 mRNA up-regulation causes proliferation arrest of a non-small cell lung carcinoma cell line (NSCLC-N6)."