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geographutoxin I

toxic peptide from Conus geographus with 22 amino acids; different from conotoxin GI; amino acid sequence given in first source

Also Known As:

GTX I

Networked: 5 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Macrocyclic Compounds: 15
  - Cyclic Peptides: 530
    - geographutoxin I: 5
Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - Cyclic Peptides: 530
    - geographutoxin I: 5

Experts

1.	Choi, Hong Lak: 1 article (11/2017)
2.	Choi, Hye Young: 1 article (11/2017)
3.	Kim, Hoon: 1 article (11/2017)
4.	Kim, Sun Moon: 1 article (11/2017)
5.	Park, Jung Soo: 1 article (11/2017)
6.	Park, Kyung Hye: 1 article (11/2017)
7.	Evrendilek, Gulsun Akdemir: 1 article (10/2014)
8.	Kurtoglu, Arzum Bahar: 1 article (10/2014)
9.	Yavuz, Recep: 1 article (10/2014)

Related Diseases

1.	Body Weight (Weight, Body) 03/01/2023 - "For acute effects, the CONTAM Panel derived a reference point (RP) of 15.3 μg/kg body weight for the sum of GTX I and III based on a BMDL10 for reduced heart rate in rats. " 11/01/1990 - "In mice, intraperitoneal injections of 1.5 mg GTX I/kg body weight of mouse for three consecutive days during the organogenetic period caused some dams to die, but neither embryotoxicity nor teratogenicity was detected. "
2.	Poisoning 10/15/2014 - "Mad honey from Rhododendron ponticum nectar is produced in a large quantity in the western Black Sea region of Turkey and causes poisoning due to consumption of grayanatoxins (GTX I and III). "
3.	Hypotension (Low Blood Pressure) 11/01/2017 - "We estimated that the minimum blood GTX-III and GTX-I levels that caused hypotension were between 17.83 and 27.3 ng/mL, and 2.52 and 4.55 ng/mL, respectively."
4.	Premature Cardiac Complexes (Extrasystoles) 02/01/1977 - "Arrhythmias induced by GTX I were characterized by extrasystoles whereas those induced by alpha-2H-GTX II were characterized by initial extrasystoles followed by a failure of the atria to follow electrical stimulation. "

Related Drugs and Biologics

1.	Plant Nectar
2.	grayanotoxin III

Related Therapies and Procedures

1.	Intraperitoneal Injections