1,2-distearoylphosphatidylethanolamine (DSPE)

RN given refers to cpd without isomeric designation

Also Known As:

DSPE; 1,2-dioctadecanoyl-sn-glycero-3-phosphoethanolamine; 1,2-distearoylphosphatidylethanolamine, (+-)-isomer; 1,2-distearoylphosphatidylethanolamine, (R)-isomer; 1,2-distearoylphosphatidylethanolamine, (S)-isomer; DC18PE; distearoyl-L-phosphatidylethanolamine

Networked: 168 relevant articles (12 outcomes, 23 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Lipids: 114793
- Membrane Lipids: 1591
  - Phospholipids: 11903
    - Glycerophosphates: 118
      - Phosphatidic Acids: 358
        Glycerophospholipids: 689
        Phosphatidylethanolamines: 167
        1,2-distearoylphosphatidylethanolamine: 168

Experts

1.	Zhang, Qiang: 6 articles (01/2019 - 12/2005)
2.	Zhang, Xuan: 4 articles (11/2017 - 12/2005)
3.	Deng, Xiongwei: 3 articles (08/2021 - 06/2017)
4.	Lu, Jianqing: 3 articles (08/2021 - 06/2017)
5.	Wu, Yan: 3 articles (08/2021 - 06/2017)
6.	Dong, Yang: 3 articles (05/2021 - 01/2020)
7.	Duan, Yourong: 3 articles (05/2021 - 01/2020)
8.	Sun, Ying: 3 articles (05/2021 - 01/2020)
9.	Wang, Ping: 3 articles (05/2021 - 07/2012)
10.	Zhou, Jianping: 3 articles (01/2020 - 04/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2020 - "DSPE-PEG-RGD@ICG demonstrated an improved accumulation in tumors and longer circulation time when compared with free ICG or DSPE-PEG@ICG. " 12/01/2023 - "Moreover, a new tumor-homing pentapeptide (SREKA) was designed, and a novel conjugation strategy between SREKA and DSPE-PEGs. " 06/13/2023 - "The in vivo evaluation experiments exhibited that the tumor inhibition rates (TIR) of PTX-ss-Zos@DSPE-PEG2k NPs were high up to 66.5% for HeLa/PTX tumor-bearing mice. " 06/13/2023 - "PTX-ss-Zos@DSPE-PEG2k NPs could be cleaved by the high-concentration GSH in cancer cells and release PTX and Zos simultaneously to inhibit MDR tumor growth synergistically without apparent systemic toxicity. " 10/01/2022 - "Furthermore, a subcutaneous cancer cell mouse model was constructed with MKN-45 cells for target efficacy and RT enhancement evaluation with DSPE-PEG-iRGD-modified RBCs (RBC-iRGD). "
2.	Breast Neoplasms (Breast Cancer) 12/01/2022 - "As expected, PPa@GA/DSPE-PEG2K nanoparticles demonstrate potent antitumor activity in a 4T1 breast tumor-bearing BALB/c mouse xenograft model. " 01/01/2021 - "Evaluations showed that DSPE-PEG-Man@EM-NPs had obvious inhibitory effects towards both MCF-7 and MDA-MB-231 human breast cancer cell lines. " 12/16/2019 - "Both DSPE@Chol-Pc and Chol-Pc effectively mediated photodynamic therapy to kill the breast cancer cells. " 09/20/2018 - "Finally, the NPY modification enhanced the targetability of MNPs(MC540)/DSPE-PEG-NPY to breast tumors, improving the trimodality UF, CT, and MR imaging performance and PDT efficacy for Y1-receptor-overexpressed breast cancer. " 07/01/2012 - "It was obvious that MDM2 can serve as a novel therapeutic target by an effective carrier system of DSPE-PEG-Amine-functionalized SWNTs, which would be very advanced and significant to therapy of breast cancer further."
3.	Glioblastoma (Glioblastoma Multiforme) 09/01/2017 - "In this in vivo experimental model, intratumoral administration of curcumin-loaded PLGA-DSPE-PEG hybrid nanoparticles was effective against glioblastoma. " 08/01/2017 - "Farnesylthiosalicylic acid-loaded PLGA-DSPE-PEG-DOTAP hybrid nanoparticles are proven to be effective against glioblastoma in both in-vitro and in-vivo experiments." 09/01/2017 - "We aimed to evaluate the antitumor activity of curcumin on glioblastoma tissue in the rat glioma-2 (RG2) tumor model when it is loaded on poly(lactic-co-glycolic acid)-1,2-distearoyl-glycerol-3-phospho-ethanolamine-N-[methoxy (polyethylene glycol)-2000] ammonium salt (PLGA-DSPE-PEG) hybrid nanoparticles. " 12/01/2019 - "Therefore, we designed and constructed an Angiopep-2 modified cationic lipid-Poly-lactic-co-glycolic acid (PLGA), Angiopep-2 (A2)/DSPE-PEG2000/DOTAP/PLGA (APDP), to transport TMZ and a DNA repair inhibitor (Dbait) into glioblastoma cells, achieving concomitant chemo-radiotherapy treatment of glioma. "
4.	Hyperthermia 07/10/2012 - "This optimal formulation (HaT-II: Hyperthermia-activated cytoToxic) displayed significantly improved stability in serum at 37 °C, and enhanced drug release rates at 41-42 °C, compared to LTSL (lyso-lipid temperature sensitive liposomes, DPPC/MSPC/DSPE-PEG₂₀₀₀=86/10/4, pH gradient drug loading). " 01/01/2017 - "This study reports on the activity of thermosensitive liposomes (TSLs) incorporating different HSPC ratios in DPPC/MSPC/PEG2000-DSPE matrix (90/10/4) plus mild hyperthermia (HT) (42 °C). "
5.	Liver Neoplasms (Liver Cancer) 11/16/2022 - "HNP coated by red blood cell membrane loaded with DSPE-PEG-cRGD peptide for the therapeutic application of liver cancer greatly prolonged in vivo circulation time and enhanced local targeting efficacy as well as low toxicity; HNP coated by the murine macrophage cell membrane (RAWM) for the DFIs treatment greatly promoted the adhesive ability of HNP on the bacteria and thereby improved the killing effect. "

Related Drugs and Biologics

1.	Liposomes (Liposome)
2.	monomethoxypolyethylene glycol (MPEG)
3.	Micelles
4.	Ethylene Glycol (Monoethylene Glycol)
5.	polyethylene glycol 2000
6.	1,2- distearoyl- sn- glycero- 3- phosphoethanolamine- N- methoxy- poly(ethylene glycol 2000)
7.	Doxorubicin (Adriamycin)
8.	Polymers
9.	Folic Acid (Vitamin M)
10.	Cholesterol

Related Therapies and Procedures

1.	Therapeutics
2.	Lasers (Laser)
3.	Photothermal Therapy
4.	Precision Medicine
5.	Photochemotherapy (Photodynamic Therapy)