decahydroquinoline-5-carboxylic acid

contains GABA moiety; RN given refers to HCl, (4a alpha,5 alpha,8a alpha)-isomer; structure given in first source

Also Known As:

DHQ-5-CA; cis-decahydroquinoline-5-carboxylic acid; decahydroquinoline; decahydroquinoline-5-carboxylic acid hydrochloride, (4aalpha,5beta,8aalpha)-isomer

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinolines: 146
      - decahydroquinoline-5-carboxylic acid: 2

Related Diseases

1.	Ventricular Fibrillation 06/01/1973 - "1. L7810 (4-carbamoyloxy-1-(4-(4-fluorophenyl)-4-oxobutyl) decahydroquinoline, has a local anaesthetic action on frog nerve 1.75 times that of procaine.2. L7810 protected anaesthetized guinea-pigs against ouabain-induced ventricular fibrillation and increased the lethal dose of ouabain.3. L7810 reduced the rate of rise of intracellularly recorded action potentials in rabbit isolated atria; the resting potential was not affected, but the duration of the action potential was prolonged.4. Unlike most drugs with local anaesthetic properties L7810 did not depress contractions in isolated atria but increased them.5. L7810 reduced the spontaneous frequency, maximum follow frequency and conduction velocity of rabbit isolated atria.6. L7810 had no blocking action on the chronotropic or positive inotropic actions of isoprenaline on isolated atrial muscle.7. In anaesthetized dogs L7810 caused a small dose-related bradycardia, and a large dose-related decrease in peripheral vascular resistance. "
2.	Pheochromocytoma 11/01/1991 - "Decahydroquinoline alkaloids: noncompetitive blockers for nicotinic acetylcholine receptor-channels in pheochromocytoma cells and Torpedo electroplax." 11/01/1991 - "In pheochromocytoma PC12 cells, (+)-cis-decahydroquinoline 195A (5-methyl-2-propyl-cis-decahydroquinoline) and (+)-perhydro-cis-decahydroquinoline 219A (2,5-dipropyl-cis-decahydroquinoline) inhibit carbamylcholine-elicited sodium flux with IC50 values of 1.0 and 1.5 microM, respectively. "
3.	Bradycardia 06/01/1973 - "1. L7810 (4-carbamoyloxy-1-(4-(4-fluorophenyl)-4-oxobutyl) decahydroquinoline, has a local anaesthetic action on frog nerve 1.75 times that of procaine.2. L7810 protected anaesthetized guinea-pigs against ouabain-induced ventricular fibrillation and increased the lethal dose of ouabain.3. L7810 reduced the rate of rise of intracellularly recorded action potentials in rabbit isolated atria; the resting potential was not affected, but the duration of the action potential was prolonged.4. Unlike most drugs with local anaesthetic properties L7810 did not depress contractions in isolated atria but increased them.5. L7810 reduced the spontaneous frequency, maximum follow frequency and conduction velocity of rabbit isolated atria.6. L7810 had no blocking action on the chronotropic or positive inotropic actions of isoprenaline on isolated atrial muscle.7. In anaesthetized dogs L7810 caused a small dose-related bradycardia, and a large dose-related decrease in peripheral vascular resistance. "

Related Drugs and Biologics

1.	Sodium
2.	Nicotinic Receptors (Nicotinic Acetylcholine Receptor)
3.	Procaine (Novocaine)
4.	Ouabain (G Strophanthin)
5.	Isoproterenol (Isoprenaline)
6.	Carbachol (Carbastat)
7.	Alkaloids
8.	2,5-dipropyldecahydroquinoline