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HLA-Cw8

Also Known As:
HLA Cw8
Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Oka, Shinichi: 2 articles (02/2008 - 01/2007)
2. Gatanaga, Hiroyuki: 2 articles (02/2008 - 01/2007)
3. Gutiérrez Rodero, Félix: 1 article (05/2008)
4. Sánchez Hellín, Victoria: 1 article (05/2008)
5. Honda, Haruhito: 1 article (02/2008)
6. Kikuchi, Yoshimi: 1 article (01/2007)
7. Tanuma, Junko: 1 article (01/2007)
8. Tachikawa, Natsuo: 1 article (01/2007)
9. Teruya, Katsuji: 1 article (01/2007)
10. Yazaki, Hirohisa: 1 article (01/2007)

Related Diseases

1. Hypersensitivity (Allergy)
01/11/2007 - "HLA-Cw8 primarily associated with hypersensitivity to nevirapine."
02/01/2008 - "Significant predisposition to nevirapine hypersensitivity has been reported in Caucasian Australians harboring HLA-DRB1*0101 with high CD4+ T-cell counts, and Sardinians and Japanese harboring HLA-Cw8. "
05/01/2008 - "The present review describes some of the adverse effects of antiretroviral drugs in which a genetic predisposition may be involved: efavirenz-induced neurological toxicity, generally associated with the 516G>T polymorphism of liver enzyme cytochrome P450 2B6 (CYP2B6); hypersensitivity reactions to nevirapine, associated with specific alleles of major histocompatibility complex, mainly the HLA-DRB1*0101 allele, which, in combination with a high CD4 lymphocyte count, has been associated with systemic reactions and hepatitis in Caucasians, and the HLA-Cw8 allele, which is associated with hypersensitivity reactions in persons from the Italian island of Sardinia and from Japan; nevirapine-induced hepatotoxicity associated with the C>T polymorphism in position 3435T of the ABCB1 (MDR-1) gene codifying for glycoprotein P (lower risk); hyperbilirubinemia in patients exposed to atazanavir or indinavir carrying the UGT1A1*28 polymorphism; peripheral neuropathy with nucleoside analogues associated with haplogroup T of the mitochondrial genome (higher risk) and with the HFE C282Y genotype of the hemochromatosis gene (lower risk); the mutation in codon 964 (R964C) of the POLG gene that codifies the mitochondrial polymerase DNA gamma described in a Thai patient with lactic acidosis; the ABCC2 gene haplotypes associated with tenofovir-induced proximal tubulopathy, and the risk of pancreatitis in persons with mutations in the CFTR and SPINK-1 genes."
2. Genetic Predisposition to Disease (Genetic Predisposition)
3. Peripheral Nervous System Diseases (PNS Diseases)
4. Pancreatitis
5. Lymphoma (Lymphomas)

Related Drugs and Biologics

1. Nevirapine (Viramune)
2. HLA-DRB1 antigen (HLA DRB1)
3. Indinavir (Crixivan)
4. Glycoproteins (Glycoprotein)
5. DNA (Deoxyribonucleic Acid)
6. Cytochrome P-450 Enzyme System (Cytochrome P450)
7. Codon (Codons)
8. atazanavir (Reyataz)
9. S-mephenytoin N-demethylase (CYP2B6)
10. efavirenz (Sustiva)

Related Therapies and Procedures

1. Autologous Transplantation