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4-fluoroestradiol

RN given refers to unlabeled (17 beta)-isomer

Also Known As:

4-fluoro-17 beta-estradiol; 4-fluoroestradiol, (17beta)-isomer, 18F-labeled

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Estranes
      - Estrenes
        Estradiol: 14115
        4-fluoroestradiol: 3
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Gonadal Hormones: 716
    - Gonadal Steroid Hormones: 7657
      - Estradiol Congeners: 358
        Estradiol: 14115
        4-fluoroestradiol: 3

Related Diseases

1.	Neoplasms (Cancer) 06/01/1994 - "17 beta-Estradiol is known to induce kidney tumors in male Syrian hamsters when administered chronically, whereas 4-fluoroestradiol does so only after an extended induction period and 2-fluoroestradiol is not carcinogenic; both fluorinated analogs are hormonally active. " 04/01/1993 - "In male Syrian hamsters, an animal model for estradiol-induced carcinogenesis, 2-fluoroestradiol was not carcinogenic, whereas 4-fluoroestradiol induced kidney tumors after a prolonged latency period, compared with estradiol (100% tumor incidence), when the compounds were administered to hamsters in hormonally equipotent doses. " 04/01/1993 - "To examine this proposed mechanism of tumor induction by estrogens, we investigated the conversion of 2- and 4-fluoroestradiol to catechol metabolites by kidney and liver microsomes of hamsters and the further conversion to methyl ethers by catechol-O-methyltransferase, and we compared the values with those obtained with nonfluorinated estrogens as substrates. "
2.	Carcinogenesis 04/01/1993 - "In male Syrian hamsters, an animal model for estradiol-induced carcinogenesis, 2-fluoroestradiol was not carcinogenic, whereas 4-fluoroestradiol induced kidney tumors after a prolonged latency period, compared with estradiol (100% tumor incidence), when the compounds were administered to hamsters in hormonally equipotent doses. " 04/01/1993 - "Microsomal hydroxylation of 2- and 4-fluoroestradiol to catechol metabolites and their conversion to methyl ethers: catechol estrogens as possible mediators of hormonal carcinogenesis."
3.	Carcinoma (Carcinomatosis) 03/01/1983 - "4-Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol. "

Related Drugs and Biologics

1.	Estradiol (Delestrogen)
2.	Estrogens (Estrogen)
3.	2-fluoroestradiol
4.	Methyl Ethers
5.	Catechol O-Methyltransferase (Methyltransferase, Catechol)
6.	Catechol Estrogens
7.	catechol (pyrocatechol)