indolizidine alkaloid from seeds of Australian legume, Castanospermum australe; structure given in first source
Also Known As:
1,6,7,8-tetrahydroxyoctahydroindolizine; 1-epicastanospermine; 6,7-diepicastanospermine; 6-epicastanospermine; castinospermine
Networked: 40 relevant articles (2 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results


1. Ouadid-Ahidouch, Halima: 2 articles (01/2013 - 08/2010)
2. Ahidouch, Ahmed: 2 articles (01/2013 - 08/2010)
3. Liu, Wei: 2 articles (05/2010 - 03/2007)
4. Whitby, Kevin: 2 articles (07/2005 - 05/2004)
5. Dimopoulos, George: 1 article (08/2014)
6. Kang, Seokyoung: 1 article (08/2014)
7. Shields, Alicia R: 1 article (08/2014)
8. Jupatanakul, Natapong: 1 article (08/2014)
9. Ortiz-Mellet, Carmen: 1 article (01/2013)
10. Fernandez, José M Garcia: 1 article (01/2013)

Related Diseases

1. Neoplasms (Cancer)
2. Body Weight (Weight, Body)
3. Infection
4. Lymphoma (Lymphomas)
05/01/1985 - "The effect of castanospermine on the oligosaccharide structures of glycoproteins from lymphoma cell lines."
05/05/1993 - "When tested in vivo in lymphoma and Madin-Darby canine kidney cells during a castanospermine-imposed glucosidase blockade, Glc alpha 1-->3DMJ interrupted the endomannosidase processing pathway as evident from a concomitant inhibition of complex oligosaccharide formation and Glc3Man release; similarly the capacity of the glucosidase II-deficient mouse lymphoma cell line (PHAR2.7) to synthesize complex oligosaccharides was blocked by Glc alpha 1-->3DMJ. "
05/01/1985 - "Castanospermine was tested directly on glucosidase I and glucosidase II in lymphoma cell extracts by using [Glc-3H]Glc3Man9GlcNAc and [Glc-3H]Glc2Man9GlcNAc as substrates. "
05/01/1985 - "The effect of castanospermine on the processing of N-linked oligosaccharides was examined in the parent mouse lymphoma cell line and in a mutant cell line that lacks glucosidase II. When the parent cell line was grown in the presence of castanospermine at 100 micrograms/ml, glucose-containing high-mannose oligosaccharides were obtained that were not found in the absence of inhibitor. "
07/01/2000 - "Employing as a model system castanospermine-treated BW5147 mouse T-lymphoma cells in which accelerated degradation of the T-cell receptor (TCR) alpha subunit takes place (Kearse et al. (1994) EMBO J., 13, 3678-3686), we noted that both lactacystin and N-acetyl-L-leucyl-L-leucyl-L-norleucinal, but not leupeptin, brought about a rapid and substantial reduction in the release of free polymannose oligosaccharides into the cytosol during pulse-chase studies, while the oligosaccharides in the intravesicular compartment remained unchanged, as measured by streptolysin O permeabilization. "
5. Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental)

Related Drugs and Biologics

1. Glycoproteins (Glycoprotein)
2. Growth Factor Receptors
3. Glycogen
4. Oligosaccharides
5. alpha-Glucosidases (Acid Maltase)
6. T-Cell Antigen Receptors (T-Cell Receptor)
7. Proteins (Proteins, Gene)
8. polymannose
9. lactacystin
10. leupeptin

Related Therapies and Procedures

1. Oral Administration