2- (2,3- dichloro- 6- methylphenylimino)imidazolidine
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Bio-Agent Context: Research Results
Related Diseases
1. | Hypotension (Low Blood Pressure)
03/01/1983
- " 1 alpha-Adrenergic activities (hypotension, bradycardia, sedation) and affinities of clonidine and two newly substituted derivatives, 2-(2,3,6-trichlorophenylimino)imidazolidine (I) and 2-(2,3-dichloro-6-methylphenylimino)imidazolidine (II), were determined in various in vitro and in vitro models.2 In anaesthetized normotensive rats, the intravenous -log doses (mol/kg) of clonidine, compound I and II required to decrease mean arterial pressure by 20% were 7.96, 8.39 and 7.79, respectively, and to reduce heart rate by 20% were 7.85, 8.23 and 7.91, respectively. "
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2. | Bradycardia
03/01/1983
- " 1 alpha-Adrenergic activities (hypotension, bradycardia, sedation) and affinities of clonidine and two newly substituted derivatives, 2-(2,3,6-trichlorophenylimino)imidazolidine (I) and 2-(2,3-dichloro-6-methylphenylimino)imidazolidine (II), were determined in various in vitro and in vitro models.2 In anaesthetized normotensive rats, the intravenous -log doses (mol/kg) of clonidine, compound I and II required to decrease mean arterial pressure by 20% were 7.96, 8.39 and 7.79, respectively, and to reduce heart rate by 20% were 7.85, 8.23 and 7.91, respectively. "
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