1,2- dihydroxy- epoxy- 1,2,3,4- tetrahydro- 5- methylchrysene

5-methyl group increases its carcinogenic activity

Also Known As:

1,2-DETMC; 5-MeC-1,2-diol-3,4-epoxide; 5-MeCDE; 5-methyl-1,2-dihydroxy-3,4-epoxy-1,2,3,4-tetrahydrochrysene; 5-methylchrysene-1,2-dihydrodiol-3,4-epoxide; 5-methylchrysene-1,2-diol-3,4-epoxide; anti-5-methylchrysene-1,2-dihydrodiol-3,4-epoxide; trans-1,2-dihydroxy-anti-3,4-epoxy-1,2,3,4-tetrahydro-5-methylchrysene; Chryseno(3,4-b)oxirene-1,2-diol, 1,2,2a,3a-tetrahydro-4-methyl-, (1alpha,2beta,2aalpha,3aalpha)-

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 10/01/1999 - "In this study, we demonstrate that the tumor suppressor protein p53 is stabilized in response to DNA damage by 5-MeCDE but fails to induce the cells' protective mechanism of G1 arrest in the human breast carcinoma cell line, MCF-7. "
2.	Neoplasms (Cancer) 01/01/1998 - "It was significantly less tumorigenic than 5-MeCDE which induced 3.1, 7.5 and 9.1 skin tumors per mouse at the same doses. " 01/01/1998 - "At the highest dose of 5-MeCDE, 20% of the tumors analysed had mutations at G of codons 12 and 13. " 01/01/1998 - "In contrast, CAA-->CTA mutations in codon 61 were rarely seen in tumors induced by 5-MeCDE. "

Related Drugs and Biologics

1.	Tumor Suppressor Protein p53
2.	Codon (Codons)