|1.||Westermann, Frank: 2 articles (06/2008 - 04/2008)|
|2.||Schwab, Manfred: 2 articles (06/2008 - 04/2008)|
|3.||Deubzer, Hedwig E: 2 articles (06/2008 - 04/2008)|
|4.||Ehemann, Volker: 2 articles (06/2008 - 04/2008)|
|5.||Kulozik, Andreas E: 2 articles (06/2008 - 04/2008)|
|6.||Witt, Olaf: 2 articles (06/2008 - 04/2008)|
|7.||Walton, Jonathan D: 2 articles (07/2006 - 02/2002)|
|8.||Sheen, Yhun Yhong: 2 articles (06/2004 - 05/2004)|
|9.||Kim, Dae-Kee: 2 articles (06/2004 - 05/2004)|
|10.||Sim, Arthur Yi Loong: 1 article (12/2015)|
06/08/2008 - "Anti-neuroblastoma activity of Helminthosporium carbonum (HC)-toxin is superior to that of other differentiating compounds in vitro."
06/08/2008 - "We have previously shown that the histone deacetylase inhibitor (HDACI) Helminthosporium carbonum (HC)-toxin induces differentiation of neuroblastoma (NB) cells. "
04/15/2008 - "Histone deacetylase inhibitor Helminthosporium carbonum (HC)-toxin suppresses the malignant phenotype of neuroblastoma cells."
|2.||Breast Neoplasms (Breast Cancer)
06/01/2004 - "Both trichostatin A and HC-toxin showed potent antiproliferative efficacy and cell cycle arrest at G2/M in T47D human breast cancer cells in a dose-dependent manner. "
06/01/2004 - "Antiproliferative effect of trichostatin A and HC-toxin in T47D human breast cancer cells."
06/01/2004 - "In this study, we have examined the antiproliferative activities of trichostatin A and HC-toxin in estrogen receptor positive human breast cancer, T47D cells. "
05/01/2004 - "Results of this study suggested that antiproliferative effects of trichostatin A and HC-toxin might be involved in estrogen receptor signaling pathway, but cell cycle arrest and apoptosis of trichostatin A and HC-toxin might not be involved in estrogen receptor system of human breast cancer cells."
05/01/2004 - "In this study, the antiproliferative activities of trichostatin A and HC-toxin were compared between estrogen receptor positive human breast cancer cell MCF-7 and estrogen receptor negative human breast cancer cell MDA-MB-468. "
02/05/2008 - "Barley leaves in which expression of the Hm1 homologue was silenced became susceptible to infection by CCR1, but only if the pathogen was able to produce HC toxin. "
07/01/2006 - "HC-toxin is an inhibitor of histone deacetylases (HDACs) in many organisms, including plants, insects, and mammals, but why inhibition of HDACs during infection by C. "
11/06/1992 - "The HM1 gene in maize controls both race-specific resistance to the fungus Cochliobolus carbonum race 1 and expression of the NADPH (reduced form of nicotinamide adenine dinucleotide phosphate)-dependent HC toxin reductase (HCTR), which inactivates HC toxin, a cyclic tetrapeptide produced by the fungus to permit infection. "
04/15/2008 - "In conclusion, nanomolar doses of the HDACI HC-toxin cause a shift to a differentiated and benign phenotype of NB cells that is associated with an activation of the RB tumor suppressor network."
01/01/2008 - "Naturally occurring cyclic tetrapeptides (CTPs) such as tentoxin (Halloin et al., Plant Physiol 1970, 45, 310-314; Saad, Phytopathology 1970, 60, 415-418), ampicidin (Darkin-Rattray, Proc Natl Acad Sci USA 1996, 93, 13143-13147), HC-toxin (Walton, Proc Natl Acad Sci USA 1987, 84, 8444-8447), and trapoxin (Yoshida and Sugita, Jpn J Cancer Res 1992, 83, 324-328; Itazaki et al., J Antibiot (Tokyo) 1990, 43, 1524-1532) have a wide range of biological activity and potential use ranging from herbicides (Walton, Proc Natl Acad Sci USA 1987, 84, 8444-8447; Judson, J Agric Food Chem 1987, 35, 451-456) to therapeutics (Loiseau, Biopolymers 2003, 69, 363-385) for malaria (Darkin-Rattray, Proc Natl Acad Sci USA 1996, 93, 13143-13147) and cancer (Yoshida and Sugita, Jpn J Cancer Res 1992, 83, 324-328). "
|1.||trichostatin A (A 300)
|3.||Histone Deacetylase Inhibitors
|4.||Histone Deacetylases (Histone Deacetylase)