micronomicin

DE 020 & DE 020 eyedrops both consist of KW 1062, benzalkonium chloride, sodium chloride, sodium hydroxide & distilled water pH 7.4; RN given refers to parent cpd; see also record for gentamicin C; structure

Also Known As:

6'-N-methylgentamicin C; DE 020; DE-020; KW 1062; KW-1062; XK-62-2; gentamicin C2b; sagamicin; D-Streptamine, O-2-amino-2,3,4,6-tetradeoxy-6-(methylamino)-alpha-D-erythro-hexopyranosyl-(1-4)-O-(3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1-6))-2-deoxy

Networked: 21 relevant articles (3 outcomes, 6 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Aminoglycosides: 5131
    - Gentamicins: 7307
      - micronomicin: 21

Experts

1.	Atkinson, Patrick J: 1 article (12/2020)
2.	Cheng, Alan G: 1 article (12/2020)
3.	Comstock, Kate: 1 article (12/2020)
4.	Greenhouse, Robert: 1 article (12/2020)
5.	Huth, Markus E: 1 article (12/2020)
6.	Lagasca, Dennis: 1 article (12/2020)
7.	Lin, Randy: 1 article (12/2020)
8.	MacDonald, Jacob P: 1 article (12/2020)
9.	O'Sullivan, Mary E: 1 article (12/2020)
10.	Perez, Adela: 1 article (12/2020)

Related Diseases

1.	Infections 01/01/1983 - "[Clinical studies on micronomicin treatment for surgical infections]." 01/01/1987 - "Single- and multiple-dose pharmacokinetics have been investigated in patients affected by bronchopulmonary infections treated with 60 mg sagamicin i.m. " 08/01/1985 - "Micronomicin (MCR) at a daily dose of 120 to 360 mg was administered to patients with severe infections who had hematopoietic disorders as underlying diseases. " 11/01/1983 - "Protective effects of intravenous administration of micronomicin (MCR) on mouse experimental infections were investigated. " 07/01/1983 - "[Clinical evaluation of micronomicin for the treatment of postoperative infections in cancer patients]."
2.	Pyelonephritis 04/01/1980 - "Of 105 patients with complicated U.T.I., 65 were administered KW-1062 at 360 mg daily, and 40 at 240 mg. KW-1062 was found to be effective in 52.5% of the 240 mg/day group, in 40% of the 360 mg/day group of complicated U.T.I., when evaluated on the basis of the criteria by the U.T.I. study group, and in 90% of patients with acute and uncomplicated pyelonephritis. "
3.	Urinary Tract Infections (Urinary Tract Infection) 01/01/1983 - "[Sensitivity distribution of bacteria newly isolated from urinary tract infections to micronomicin]." 10/01/1980 - "KW-1062 was administered intramuscularly at a daily dose of 360 mg for 5 days to 50 patients suffering from chronic complicated urinary tract infections. " 10/01/1980 - "[Clinical effect of KW-1062 on chronic complicated urinary tract infection]." 01/01/1987 - "[Study of efficacy and safety of micronomicin administered by intravenous drip infusion in treatment against complicated urinary tract infections]." 08/01/1984 - "[Clinical studies on intravenous drip-infusion of micronomicin for complicated urinary tract infections]."
4.	Ototoxicity 03/01/1982 - "8) Ototoxicity of micronomicin in guinea pigs was found to be approximately four times less than that of GM. " 02/01/1980 - "[Animal test for evaluation of ototoxicity and safety of KW-1062 (author's transl)]." 06/01/1977 - "KW-1062 showed urinative effect and ototoxicity. " 12/22/2020 - "In contrast, they showed different degrees of ototoxicity in cochlear explants, with gentamicin C2b being the least and gentamicin C2 the most ototoxic. " 10/01/1983 - "[Ototoxicity of micronomicin sulfate--audiometric assessment]."
5.	Respiratory Tract Infections (Respiratory Tract Infection) 09/01/1984 - "[Fundamental and clinical studies of intravenous drip infusion of micronomicin in respiratory tract infection]." 03/01/1982 - "10) Micronomicin was effective on 964 cases out of 1,469 cases from 127 research facilities in Japan (65.6%), suggesting its favorable activity against respiratory tract infections and against urinary tract infections. " 09/01/1984 - "A study was carried out with the aminoglycoside antibiotic micronomicin (MCR) to determine its clinical efficacy in respiratory infections on the one hand and its serum levels on the other. "

Related Drugs and Biologics

1.	Anti-Bacterial Agents (Antibiotics)
2.	3,6-dimethylaminodibenzopyriodonium citrate
3.	Aminoglycosides
4.	Sulfates (Sulfates, Inorganic)
5.	micronomicin
6.	Therapeutic Uses
7.	Gentamicins (Gentamicin)
8.	Levofloxacin (Levaquin)
9.	Imipenem
10.	Cefmenoxime (Cefmax)

Related Therapies and Procedures

1.	Intravenous Administration
2.	Intravenous Infusions
3.	Therapeutics