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picrotoxinin receptor

works via GABA receptor

Also Known As:

picrotoxin receptor; picrotoxin receptors; picrotoxinin receptors; receptor, picrotoxin; receptor, picrotoxinin

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Carrier Proteins: 12999
    - Membrane Transport Proteins: 589
      - Ion Channels: 6731
        Chloride Channels: 1799
        GABA-A Receptors: 2216
        picrotoxinin receptor: 2
        Ligand-Gated Ion Channels: 221
        Cysteine Loop Ligand-Gated Ion Channel Receptors: 14
        GABA-A Receptors: 2216
        picrotoxinin receptor: 2
  - Membrane Proteins: 10078

Related Diseases

1.	Seizures (Absence Seizure) 02/01/1989 - "The present findings are compatible with other evidence that lindane and Ro 5-4864 act at the picrotoxinin receptor of the GABAA-activated chloride channel and that systemic administration of agents acting at this site may produce a constellation of effects, including seizures, hypothermia and anorexia."
2.	Hypothermia 02/01/1989 - "The present findings are compatible with other evidence that lindane and Ro 5-4864 act at the picrotoxinin receptor of the GABAA-activated chloride channel and that systemic administration of agents acting at this site may produce a constellation of effects, including seizures, hypothermia and anorexia."
3.	Epilepsy (Aura) 01/01/1987 - "Decreased GABA, benzodiazepine, and picrotoxinin receptor binding in brains of rats after cobalt-induced epilepsy." 01/01/1987 - "According to our results, in cobalt-induced epilepsy the GABA/benzodiazepine/picrotoxinin receptor complex is modulated in the focal area; this may lead to a defect in chloride conductance, which in turn induces disturbed control of neuronal activity in the epileptic focus."
4.	Anorexia 02/01/1989 - "The present findings are compatible with other evidence that lindane and Ro 5-4864 act at the picrotoxinin receptor of the GABAA-activated chloride channel and that systemic administration of agents acting at this site may produce a constellation of effects, including seizures, hypothermia and anorexia."

Related Drugs and Biologics

1.	Chloride Channels (Chloride Channel)
2.	gamma-Aminobutyric Acid (GABA)
3.	Cobalt
4.	Chlorides
5.	Benzodiazepines
6.	Hexachlorocyclohexane (gamma-Hexachlorocyclohexane)
7.	4'-chlorodiazepam