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2-fluoroestradiol

in contrast to 4-fluoroestradiol above cpd is not a carcinogen

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Estranes
      - Estrenes
        Estradiol: 14115
        2-fluoroestradiol: 4
Hormones, Hormone Substitutes, and Hormone Antagonists
- Hormones: 80400
  - Gonadal Hormones: 716
    - Gonadal Steroid Hormones: 7657
      - Estradiol Congeners: 358
        Estradiol: 14115
        2-fluoroestradiol: 4

Related Diseases

1.	Neoplasms (Cancer) 09/01/1986 - "After 7 months, 75% of the estradiol-treated hamsters had kidney tumors, while in animals exposed to 2-fluoroestradiol renal carcinoma could not be detected. " 06/01/1994 - "17 beta-Estradiol is known to induce kidney tumors in male Syrian hamsters when administered chronically, whereas 4-fluoroestradiol does so only after an extended induction period and 2-fluoroestradiol is not carcinogenic; both fluorinated analogs are hormonally active. " 04/01/1993 - "In male Syrian hamsters, an animal model for estradiol-induced carcinogenesis, 2-fluoroestradiol was not carcinogenic, whereas 4-fluoroestradiol induced kidney tumors after a prolonged latency period, compared with estradiol (100% tumor incidence), when the compounds were administered to hamsters in hormonally equipotent doses. "
2.	Carcinogenesis 04/01/1993 - "In male Syrian hamsters, an animal model for estradiol-induced carcinogenesis, 2-fluoroestradiol was not carcinogenic, whereas 4-fluoroestradiol induced kidney tumors after a prolonged latency period, compared with estradiol (100% tumor incidence), when the compounds were administered to hamsters in hormonally equipotent doses. " 09/01/1986 - "To understand the mechanism of hormonal carcinogenesis, estrogen-induced renal carcinoma in male Syrian hamsters was investigated using estradiol and 2-fluoroestradiol. "
3.	Renal Cell Carcinoma (Grawitz Tumor) 09/01/1986 - "After 7 months, 75% of the estradiol-treated hamsters had kidney tumors, while in animals exposed to 2-fluoroestradiol renal carcinoma could not be detected. " 09/01/1986 - "To understand the mechanism of hormonal carcinogenesis, estrogen-induced renal carcinoma in male Syrian hamsters was investigated using estradiol and 2-fluoroestradiol. "
4.	Carcinoma (Carcinomatosis) 03/01/1983 - "2-Fluoroestradiol, a modified estrogen, did not induce renal clear-cell carcinoma in male Syrian hamsters despite its estrogenic potency, which is comparable to that of estradiol. "

Related Drugs and Biologics

1.	Estradiol (Delestrogen)
2.	Estrogens (Estrogen)
3.	4-fluoroestradiol